Methyl 3-amino-3-(4-fluorophenyl)propanoate

Base Information

Chemical Name:Methyl 3-amino-3-(4-fluorophenyl)propanoate
CAS No.:181519-32-4
Molecular Formula:C₁₀H₁₂FNO₂
Molecular Weight:197.209
Hs Code.:
European Community (EC) Number:631-467-4
Mol file:181519-32-4.mol

Synonyms:methyl 3-amino-3-(4-fluorophenyl)propanoate;181519-32-4;Methyl 3-amino-3-(4-fluorophenyl)propanoate HCl;Benzenepropanoicacid,-amino-4-fluoro-,methylester,(S)-;SCHEMBL7236821;BULPFQGZGPHEBO-UHFFFAOYSA-N;Propionic acid, 3-amino-3-(4-fluorophenyl)-, methyl ester;AKOS009269262;BS-42567;FT-0754801;EN300-53957;N16391;Z366644130

Suppliers and Price of Methyl 3-amino-3-(4-fluorophenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 3-amino-3-(4-fluorophenyl)propanoate

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:197.08520679
Heavy Atom Count:14
Complexity:191

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CC(C1=CC=C(C=C1)F)N

Technology Process of Methyl 3-amino-3-(4-fluorophenyl)propanoate

There total 3 articles about Methyl 3-amino-3-(4-fluorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 325-89-3
3-amino-3-(4-fluorophenyl)propanoic acid

: 181519-32-4
3-amino-3-(4-fluorophenyl)propionic acid methyl ester

Guidance literature:: With hydrogenchloride; In water; for 12h; Reflux;
DOI:10.1002/adsc.200900676

Reference yield: 74.0%

: 225517-06-6
3-(N-tert-butyloxycarbonyl)amino-3-(4-fluorophenyl)propionic acid, methyl ester

: 181519-32-4
3-amino-3-(4-fluorophenyl)propionic acid methyl ester

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 181519-32-4
3-amino-3-(4-fluorophenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / 6 h / Reflux; Inert atmosphere

2: sulfuric acid / 16 h / Reflux; Inert atmosphere

With sulfuric acid; ammonium acetate; In ethanol;
DOI:10.3762/bjoc.9.31