LY-3009120

Base Information

Chemical Name:LY-3009120
CAS No.:1454682-72-4
Molecular Formula:C23H29FN6O
Molecular Weight:424.521
Hs Code.:2933998090
Mol file:1454682-72-4.mol

Synonyms:LY-3009120;Urea, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-;N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-;DP 4978;N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea

Suppliers and Price of LY-3009120

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
LY-3009120
100mg
$ 2229.00

TRC
LY3009120
10mg
$ 2410.00

TRC
LY3009120
5mg
$ 1235.00

Tocris
LY3009120 ≥98%(HPLC)
10
$ 101.00

DC Chemicals
LY3009120 >98%
1 g
$ 2200.00

DC Chemicals
LY3009120 >98%
100 mg
$ 500.00

Crysdot
LY-3009120 98+%
100mg
$ 695.00

Crysdot
LY-3009120 98+%
50mg
$ 390.00

ChemScene
LY3009120 99.01%
50mg
$ 400.00

ChemScene
LY3009120 99.01%
25mg
$ 210.00

Total 17 raw suppliers

Chemical Property of LY-3009120

Chemical Property:

PKA:13.52±0.70(Predicted)
PSA：91.83000
Density:1 +-.0.06 g/cm3(Predicted)
LogP:5.58400
Solubility.:insoluble in H2O; insoluble in EtOH; ≥4.25 mg/mL in DMSO with gentle warming and ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

LY-3009120 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses LY 3009120 is a potent pan-Rad inhibitor used in the inhibition of tumors. Dose-dependant inhibition.

Technology Process of LY-3009120

There total 18 articles about LY-3009120 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1454682-74-6
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1454682-77-9
7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl trifluoromethanesulfonate

: 1454682-72-4
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido(2,3-d)pyrimidin-6-yl)phenyl)urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 50 ℃; Reagent/catalyst; Inert atmosphere;

Reference yield: 70.0%

: 1454682-74-6
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1454682-79-1
6-bromo-N,7-dimethylpyrido[2,3-d]pyrimidin-2-amine

: 1454682-72-4
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido(2,3-d)pyrimidin-6-yl)phenyl)urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 85 ℃; Inert atmosphere;

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1454682-72-4
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido(2,3-d)pyrimidin-6-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; potassium nitrate / -10 - 20 °C / Cooling with ice; Inert atmosphere

2.1: iron; hydrogenchloride / ethyl acetate; water / 20 - 30 °C / Inert atmosphere

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Isopropyl acetate / 50 °C / Inert atmosphere; Reflux

4.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

4.2: 90 °C

5.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 50 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium acetate; iron; sodium hydrogencarbonate; potassium nitrate; In tetrahydrofuran; 1,4-dioxane; Isopropyl acetate; water; ethyl acetate;