5-Bromo-2-fluoro-4-methylaniline

Base Information

• Chemical Name: 5-Bromo-2-fluoro-4-methylaniline
• CAS No.: 945244-29-1
• Molecular Formula: C7H7BrFN
• Molecular Weight: 204.042
• Hs Code.: 2921430090
• Mol file: 945244-29-1.mol

Synonyms:5-Bromo-2-fluoro-4-methylaniline;(5-Bromo-2-fluoro-4-methylphenyl)amine;4-Amino-2-bromo-5-fluorotoluene, 5-Bromo-2-fluoro-p-toluidine

Chemical Property of 5-Bromo-2-fluoro-4-methylaniline

Chemical Property:

• Boiling Point: 244℃
• PKA: 2.56±0.10(Predicted)
• Flash Point: 101℃
• PSA: 26.02000
• Density: 1.589
• LogP: 3.06000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-?Bromo-?2-?fluoro-?4-?methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-?Bromo-?2-?fluoro-?4-?methylaniline is a reagent used in the synthesis of Pan-RAF inhibitors which may be used in the treatment of cancers.

Technology Process of 5-Bromo-2-fluoro-4-methylaniline

There total 3 articles about 5-Bromo-2-fluoro-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-bromo-4-fluoro-2-methyl-5-nitro-benzene (170098-98-3) → 5-bromo-2-fluoro-4-methylaniline (945244-29-1)

Guidance literature:

With hydrogen; In ethanol; under 2062.71 Torr;

Reference yield: 30.0%

tin(II) chloride dihdyrate (10025-69-1) + 1-bromo-4-fluoro-2-methyl-5-nitro-benzene (170098-98-3) → 5-bromo-2-fluoro-4-methylaniline (945244-29-1)

Guidance literature:

In ethanol;

Reference yield:

2-Bromo-5-fluorotoluene (452-63-1) → 5-bromo-2-fluoro-4-methylaniline (945244-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: nitronium tetrafluoroborate / dichloromethane

2: ethanol

With nitronium tetrafluoroborate; In ethanol; dichloromethane;

upstream raw materials:

1-bromo-4-fluoro-2-methyl-5-nitro-benzene

tin(II) chloride dihdyrate

2-Bromo-5-fluorotoluene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 945244-29-1 5-Bromo-2-fluoro-4-methylaniline

Send

Send

Metric Ton KG G Pound L ML

Send

Send