114772-43-9 Usage
Uses
Used in Pharmaceutical Research:
[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-, methyl ester is used as a potential active pharmaceutical ingredient (API) for the development of new drugs due to its unique structure and possible biological activity.
Used in Organic Synthesis:
In the field of organic synthesis, [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-, methyl ester serves as a valuable intermediate or building block for the synthesis of more complex organic molecules.
Used in Medicinal Chemistry:
[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-, methyl ester is used as a structural component in the design and development of novel therapeutic agents, particularly those targeting infectious diseases or other conditions that may benefit from its potential antimicrobial or antifungal properties.
Used in Antimicrobial Applications:
In the medical industry, [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-, methyl ester is used as an antimicrobial agent for the development of new treatments against bacterial and fungal infections, given its potential biological activity.
Used in Antifungal Applications:
Similarly, in the field of antifungal drug development, [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-, methyl ester is used as an antifungal agent to create new medications for treating fungal infections, leveraging its possible antifungal properties.
Check Digit Verification of cas no
The CAS Registry Mumber 114772-43-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,7 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114772-43:
(8*1)+(7*1)+(6*4)+(5*7)+(4*7)+(3*2)+(2*4)+(1*3)=119
119 % 10 = 9
So 114772-43-9 is a valid CAS Registry Number.
114772-43-9Relevant academic research and scientific papers
Imidazole ethers having a II antagonist activity
-
, (2008/06/13)
Compounds of general formula (I) STR1 wherein E is O or S; R is C 1 -C 5 straight, branched or cyclic alkyl or C 2 -C 5 alkenyl; X can be H, F, Cl, Br, I, CF 3 ; n is an integer 1 to 4; m is an integer 0 to 4; A and B are 5- or 6- membered aromatic carboc
Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives
Carini, David J.,Duncia, John V.,Aldrich, Paul E.,Chiu, Andrew T.,Johnson, Alexander L.,et al.
, p. 2525 - 2547 (2007/10/02)
A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared.These N-(biphenylylmethyl)imidazoles, e.g. 2-butyl-1--4-chloro-5-(hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously.It has been found that the acidic group at the 2'-position of the biphenyl is essential.Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency.The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective.The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension.
