JIB-04

Base Information

Chemical Name:JIB-04
CAS No.:199596-05-9
Molecular Formula:C17H13ClN4
Molecular Weight:308.76492
Hs Code.:
Mol file:199596-05-9.mol

Synonyms:JIB-04;JIB-04 (NSC 693627);JIB04/JIB-04;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone;5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine;NSC 693627;5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone JIB-04(NSC 693627);JIB-04 5-Chloro-2(1H)-pyridinone (2E)-(phenyl-2-pyridinylmethylene)hydrazone

Suppliers and Price of JIB-04

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
JIB 04
10mg
$ 423.00

TRC
JIB-04
10mg
$ 110.00

Tocris
JIB04 ≥99%(HPLC)
50
$ 718.00

Tocris
JIB04 ≥99%(HPLC)
10
$ 169.00

Sigma-Aldrich
JIB-04 ≥98% (HPLC)
5mg
$ 99.20

Sigma-Aldrich
JIB-04 ≥98% (HPLC)
25mg
$ 401.00

DC Chemicals
JIB-04 >98%
250 mg
$ 600.00

CSNpharm
JIB-04
5mg
$ 44.00

CSNpharm
JIB-04
10mg
$ 74.00

CSNpharm
JIB-04
50mg
$ 186.00

Total 26 raw suppliers

Chemical Property of JIB-04

Chemical Property:

Boiling Point:472.9±55.0 °C(Predicted)
PKA:11.00±0.10(Predicted)
Density:1.24±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
Solubility.:DMSO: soluble10mg/mL, clear

Purity/Quality:

99%, ^*data from raw suppliers

JIB 04 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases?in vitro, in cancer cells and in tumors?in vivo.?IC50?= 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.??Reduces tumor burden and prolongs life in a mouse model.1?Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2?Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3
Uses JIB-04 is a specific inhibitor of Jumonji demethylases. JIB-04 has been used in sulforhodamine B cell growth assay. It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A).

Technology Process of JIB-04

There total 2 articles about JIB-04 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%