Histone Demethylase inhibitors

Histone demethylase inhibitors are a class of compounds that target enzymes responsible for removing methyl groups from histone proteins, known as histone demethylases (HDMs). These enzymes play a crucial role in regulating chromatin structure and gene expression by reversing histone methylation marks, thereby influencing transcriptional activation or repression of genes. Dysregulation of histone demethylases is implicated in various diseases, including cancer and neurodevelopmental disorders, where aberrant histone methylation patterns contribute to disease progression.