2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

• Chemical Name: 2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS No.: 1260106-29-3
• Molecular Formula: C16H19BN2O2
• Molecular Weight: 282.15
• Mol file: 1260106-29-3.mol

Synonyms:5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2,3'-bipyridine

Chemical Property of 2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

• PSA: 44.24000
• LogP: 2.44280

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 3 articles about 2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-2,3′-bipyridine (774-53-8) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3'-bipyridine (1260106-29-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In 1,4-dioxane; for 5h; Inert atmosphere; Reflux;

Reference yield:

3-pyridylboronic acid (1692-25-7) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3'-bipyridine (1260106-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 5 h / Inert atmosphere; Heating

2: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

2-iodo-5-bromopyridine (223463-13-6) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3'-bipyridine (1260106-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 5 h / Inert atmosphere; Heating

2: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

upstream raw materials:

3-pyridylboronic acid

5-bromo-2,3′-bipyridine

bis(pinacol)diborane

2-iodo-5-bromopyridine