Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate
CAS No.:158602-35-8
Molecular Formula:C12H21NO4
Molecular Weight:243.29944
Hs Code.:2933990090
European Community (EC) Number:967-085-2
Mol file:158602-35-8.mol

Synonyms:158602-35-8;TERT-BUTYL 3-(2-ETHOXY-2-OXOETHYL)AZETIDINE-1-CARBOXYLATE;Ethyl 1-Boc-3-azetidineacetate;1-Boc-3-azetidineacetic acid ethyl ester;3-Azetidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester;MFCD11616049;Ethyl N-BOC-azetidin-3-ylacetate;1-Boc-3-(2-ethoxy-2-oxoethyl)azetidine;SCHEMBL1661739;AMY3848;HTYZZXUWPRCEIN-UHFFFAOYSA-N;AKOS022182312;DS-3106;PB20607;SY098255;E1390;EN300-83197;Ethyl 1-(tert-Butoxycarbonyl)-3-azetidineacetate;A883415;3-ethoxycarbonylmethyl-azetidine-1-carboxylic acid tert-butyl ester;TERT-BUTYL3-(2-ETHOXY-2-OXOETHYL)AZETIDINE-1-CARBOXYLATE;1,1-dimethylethyl 3-[2-(ethyloxy)-2-oxoethyl]-1-azetidinecarboxylate

Suppliers and Price of Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl3-(2-Ethoxy-2-oxoethyl)azetidine-1-carboxylate
50mg
$ 45.00

TCI Chemical
Ethyl 1-(tert-Butoxycarbonyl)-3-azetidineacetate
1G
$ 93.00

Synthonix
Ethyl1-Boc-3-azetidineacetate 97.0%
25g
$ 150.00

SynQuest Laboratories
Ethyl 1-Boc-3-azetidineacetate
1 g
$ 75.00

SynQuest Laboratories
Ethyl 1-Boc-3-azetidineacetate
5 g
$ 250.00

SynQuest Laboratories
Ethyl 1-Boc-3-azetidineacetate
25 g
$ 750.00

Matrix Scientific
Ethyl 1-Boc-3-azetidineacetate
5g
$ 781.00

Matrix Scientific
Ethyl 1-Boc-3-azetidineacetate
1g
$ 284.00

Crysdot
tert-Butyl3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate 95+%
5g
$ 158.00

Chem-Impex
Ethyl1-(tert-butoxycarbonyl)-3-azetidineacetate,≥98%(GC) ≥98%(GC)
1G
$ 104.00

Total 22 raw suppliers

Chemical Property of Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Chemical Property:

Boiling Point:303.0±15.0 °C(Predicted)
PKA:-1.89±0.40(Predicted)
PSA：55.84000
Density:1.089±0.06 g/cm3(Predicted)
LogP:1.74440
Storage Temp.:2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:243.14705815
Heavy Atom Count:17
Complexity:289

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(2-Ethoxy-2-oxoethyl)azetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1CN(C1)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

There total 4 articles about Tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1002355-96-5
tert-butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate

: 158602-35-8
tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tert-butyl methyl ether; water; for 0.5h; under 2068.65 Torr; Inert atmosphere;

Reference yield: 93.0%

: 183062-96-6
2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid

: 158602-35-8
tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In diethyl ether; ethanol; at 20 ℃;

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 158602-35-8
tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 40 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / water; tert-butyl methyl ether / 0.5 h / 2068.65 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In dichloromethane; tert-butyl methyl ether; water;