TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
• CAS No.: 152537-03-6
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• Hs Code.: 2933990090
• Mol file: 152537-03-6.mol

Synonyms:N-BOC-Azetidin-3-ylethanol;1-BOC-3-(HYDROXYETHYL)AZETIDINE;3-(2-hydroxyethyl)azetidine-1-carboxylic acid tert-butyl ester;t-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate;

Chemical Property of TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 287.4±13.0 °C(Predicted)
• PKA: 15.05±0.10(Predicted)
• PSA: 49.77000
• Density: 1.092±0.06 g/cm3(Predicted)
• LogP: 1.17200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3-(2-Hydroxyethyl)azetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE

There total 6 articles about TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid (183062-96-6) → tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (152537-03-6)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 92.0%

tert-butyl 3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate (497160-14-2) → tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (152537-03-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

Reference yield:

Ethyl Azetidin-3-ylacetate-formate (1378964-44-3) + tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate (158602-35-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (152537-03-6)

Guidance literature:

With potassium hydrogensulfate; lithium borohydride; triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

Ethyl Azetidin-3-ylacetate-formate

tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate

di-tert-butyl dicarbonate

2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid

Downstream raw materials:

tert-butyl 3-(2-iodoethyl)azetidine-1-carboxylate

3-{2-[3-(4-chlorophenoxy)phenoxy]ethyl}azetidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-(2-(4-bromo-2-(trifluoromethyl)phenoxy)ethyl)azetidine-1-carboxylate

2-(azetidin-3-yl)ethanol

Refernces

• 1、 -. "POLYCYCLIC COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES". Paragraph 1368; 1369. . Retrieved 2020/03/29.
• 2、 -. "?-LACTAMASE INHIBITOR AND USE THEREOF". Paragraph 0206; 0207. . Retrieved 2020/12/10.