2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1)

Base Information

• Chemical Name: 2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1)
• CAS No.: 869556-76-3
• Molecular Formula: C7H10ClNO3
• Molecular Weight: 191.6122
• Mol file: 869556-76-3.mol

Synonyms:2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1);2-FURANACETIC ACID,α-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1)

Chemical Property of 2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1)

Chemical Property:

• PSA: 65.46000
• LogP: 1.95470

Purity/Quality:

99% ^*data from raw suppliers

methyl 2-amino-2-(furan-2-yl)acetate hydrochloride 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1)

There total 2 articles about 2-FURANACETIC ACID,A-AMINO-,METHYL ESTER,HYDROCHLORIDE (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-amino-2-(furan-2-yl)acetate (70946-43-9) → methyl 2-amino-2-(furan-2-yl)acetate hydrochloride (869556-76-3)

Guidance literature:

With acetyl chloride; In methanol; for 0.166667h;

Reference yield:

methanol (67-56-1) + DL-2-amino-2-(furan-2-yl)acetic acid (17119-54-9,64757-64-8) → methyl 2-amino-2-(furan-2-yl)acetate hydrochloride (869556-76-3)

Guidance literature:

With thionyl chloride; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja506031h

Reference yield: 78.0%

methyl 2-amino-2-(furan-2-yl)acetate hydrochloride (869556-76-3) → methyl 2-amino-2-(furan-2-yl)acetate (70946-43-9)

Guidance literature:

methyl 2-amino-2-(furan-2-yl)acetate hydrochloride; With formic acid; zinc; In methanol; at 0 - 20 ℃;

With sodium carbonate; In water; pH=10;

upstream raw materials:

methyl 2-amino-2-(furan-2-yl)acetate

methanol

DL-2-amino-2-(furan-2-yl)acetic acid

Downstream raw materials:

methyl 2-amino-2-(furan-2-yl)acetate

methyl 2-(4'-((3''-fluoro)benzyloxy)benzyl)amino-2-(furan-2-yl)acetate

Refernces

• 1、 Salomé, Christophe,Salomé-Grosjean, Elise,Stables, James P.,Kohn, Harold. "Merging the structural motifs of functionalized amino acids and α-Aminoamides: Compounds with Significant Anticonvulsant Activities". supporting information; experimental part. p. 3756 - 3771. Retrieved 2010/07/16.