5-bromo-N-cyclopropylthiophene-2-carboxamide

Base Information

Chemical Name:5-bromo-N-cyclopropylthiophene-2-carboxamide
CAS No.:495382-05-3
Molecular Formula:C8H8BrNOS
Molecular Weight:246.128
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40400484
Wikidata:Q82203487
Mol file:495382-05-3.mol

Synonyms:495382-05-3;5-bromo-N-cyclopropylthiophene-2-carboxamide;5-Bromo-N-cyclopropyl-2-thiophenecarboxamide;SCHEMBL12564971;DTXSID40400484;VUA38205;MFCD03071662;STK450831;AKOS003303499;BS-38153;CS-0327164

Suppliers and Price of 5-bromo-N-cyclopropylthiophene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-Bromo-N-cyclopropylthiophene-2-carboxamide 95+%
5g
$ 826.00

Chemenu
5-Bromo-N-cyclopropylthiophene-2-carboxamide 95%
5g
$ 780.00

ChemBridge Corporation
5-bromo-N-cyclopropyl-2-thiophenecarboxamide 95%
1 g
$ 46.00

Arctom
5-Bromo-N-cyclopropylthiophene-2-carboxamide ≥95%
1g
$ 275.00

Arctom
5-Bromo-N-cyclopropylthiophene-2-carboxamide ≥95%
5g
$ 826.00

American Custom Chemicals Corporation
5-BROMO-N-CYCLOPROPYL-2-THIOPHENECARBOXAMIDE 95.00%
5G
$ 1334.03

American Custom Chemicals Corporation
5-BROMO-N-CYCLOPROPYL-2-THIOPHENECARBOXAMIDE 95.00%
1G
$ 764.03

Total 2 raw suppliers

Chemical Property of 5-bromo-N-cyclopropylthiophene-2-carboxamide

Chemical Property:

Vapor Pressure:1.34E-05mmHg at 25°C
Boiling Point:367.7°C at 760 mmHg
Flash Point:176.2°C
PSA：57.34000
Density:1.69g/cm³
LogP:2.79370
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:244.95100
Heavy Atom Count:12
Complexity:196

Purity/Quality:: 5-Bromo-N-cyclopropylthiophene-2-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1NC(=O)C2=CC=C(S2)Br

Technology Process of 5-bromo-N-cyclopropylthiophene-2-carboxamide

There total 3 articles about 5-bromo-N-cyclopropylthiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 7311-63-9
5-bromothiophene-2-carboxylic acid

: 765-30-0
Cyclopropylamine

: 495382-05-3
5-bromo-N-cyclopropylthiophene-2-carboxamide

Guidance literature:: 5-bromothiophene-2-carboxylic acid; Cyclopropylamine; In dichloromethane; at 0 ℃; for 0.0833333h;

With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane; at 0 - 5 ℃; for 0.5h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 13h;

Reference yield:

: 7311-63-9
5-bromothiophene-2-carboxylic acid

: 495382-05-3
5-bromo-N-cyclopropylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 150 °C / Microwave irradiation

2: dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml200143c