Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate

Base Information

• Chemical Name: Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate
• CAS No.: 1166829-70-4
• Molecular Formula: C16H27BO4
• Molecular Weight: 294.199
• Mol file: 1166829-70-4.mol

Synonyms:Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate

Chemical Property of Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate

Chemical Property:

• Boiling Point: 328.3±44.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.02±0.1 g/cm3(Predicted)
• LogP: 3.29750
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate

There total 7 articles about Ethyl-2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3- enyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)acetate (1166829-70-4)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 70 ℃; for 23h; Inert atmosphere; Sealed tube;

Reference yield: 73.5%

ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate (1166829-72-6) + bis(pinacol)diborane (73183-34-3) → ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)acetate (1166829-70-4)

Guidance literature:

ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate; bis(pinacol)diborane; With 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; In 1,4-dioxane; for 0.0833333h; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 18h;

Reference yield: 50.0%

(4-oxocyclohexylidene)acetic acid ethyl ester (159454-98-5) + bis(pinacol)diborane (73183-34-3) → ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)acetate (1166829-70-4)

Guidance literature:

(4-oxocyclohexylidene)acetic acid ethyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; tert-butyl methyl ether; at -78 ℃;

bis(pinacol)diborane; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium bromide; In 1,4-dioxane; at 110 ℃;

DOI:10.1021/acsmedchemlett.1c00236

upstream raw materials:

ethyl 4-oxocyclohexaneacetate

ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate

bis(pinacol)diborane

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

Downstream raw materials:

ethyl [4-(2-fluoro-4-hydroxyphenyl)cyclohex-3-en-1-yl]acetate

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