1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone

Base Information

• Chemical Name: 1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone
• CAS No.: 100959-21-5
• Molecular Formula: C8H6BrClO2
• Molecular Weight: 249.48904
• Mol file: 100959-21-5.mol

Synonyms:1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone

Chemical Property of 1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone

Chemical Property:

• PSA: 37.30000
• LogP: 2.57620

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone

There total 5 articles about 1-(5-bromo-2-hydroxyphenyl)-2-chloroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-bromo-phenol (106-41-2) + acetyl chloride (75-36-5) → 2-hydroxy-5-bromophenacyl chloride (100959-21-5)

Guidance literature:

With aluminium trichloride; at 40 ℃; for 3h;

DOI:10.1007/BF02219246

Reference yield:

4-bromo-phenol (106-41-2) + chloroacetyl chloride (79-04-9) → 2-hydroxy-5-bromophenacyl chloride (100959-21-5)

Guidance literature:

4-bromo-phenol; chloroacetyl chloride;

With aluminium trichloride; at 140 ℃; Further stages.;

DOI:10.1021/ja068969w

Reference yield:

chloro-acetic acid-(4-bromo-phenyl ester) (36559-93-0) → 2-hydroxy-5-bromophenacyl chloride (100959-21-5)

Guidance literature:

With aluminium trichloride; at 110 ℃;

upstream raw materials:

chloro-acetic acid-(4-bromo-phenyl ester)

4-bromo-phenol

acetyl chloride

chloroacetyl chloride

Downstream raw materials:

5-bromo-3(2H)-benzofuranone

(5-Bromobenzofuran-3-yl)acetic acid ethyl ester

Refernces

• 1、 Kozikowski, Alan P.,Gaisina, Irina N.,Yuan, Hongbin,Petukhov, Pavel A.,Blond, Sylvie Y.,Fedolak, Allison,Caldarone, Barbara,McGonigle, Paul. "Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. Possible new GSK-3β therapies for bipolar disorders". . p. 8328 - 8332. Retrieved 2008/02/09.