5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine

Base Information

Chemical Name:5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine
CAS No.:1134156-51-6
Molecular Formula:C21H22N6O4
Molecular Weight:422.443
Hs Code.:
Mol file:1134156-51-6.mol

Synonyms:5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine;5'-O-[(4-Cyanophenyl)methyl]-2',3'-O-(1-methylethylidene)adenosine

Suppliers and Price of 5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Crysdot
4-((((3AR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile 97%
100mg
$ 396.00

Total 8 raw suppliers

Chemical Property of 5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine

Chemical Property:

Boiling Point:674.6±65.0 °C(Predicted)
PKA:3.56±0.10(Predicted)
PSA：130.33000
Density:1.53±0.1 g/cm3(Predicted)
LogP:2.49568

Purity/Quality:

97% ^*data from raw suppliers

4-((((3AR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile 97% ^*data from reagent suppliers

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Technology Process of 5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine

There total 3 articles about 5'-O-(4-Cyanobenzyl)-2',3'-O-isopropylidene adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1134156-49-2
4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

: 1134156-51-6
4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: With ammonia; In methanol; at 110 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acs.jmedchem.9b01709

Reference yield:

: 39824-26-5
6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

: 1134156-51-6
4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2: ammonia / methanol / 2 h / 110 °C / Inert atmosphere; Microwave irradiation

With ammonia; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.9b01709

Reference yield:

: 17201-43-3
4-cyanobenzyl bromide

: 1134156-51-6
4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2: ammonia / methanol / 2 h / 110 °C / Inert atmosphere; Microwave irradiation

With ammonia; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.9b01709