4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Base Information

Chemical Name:4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile
CAS No.:1134156-49-2
Molecular Formula:C₂₁H₂₀ClN₅O₄
Molecular Weight:441.874
Hs Code.:

Synonyms:4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

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Chemical Property of 4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

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Technology Process of 4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

There total 1 articles about 4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 39824-26-5
6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine

: 17201-43-3
4-cyanobenzyl bromide

: 1134156-49-2
4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere;
DOI:10.1021/jm801627a

Reference yield: 82.0%

: 1134156-49-2
4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

: 1134156-51-6
4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: With ammonia; In methanol; at 110 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acs.jmedchem.9b01709

Reference yield:

: 1134156-49-2
4-((((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

: 1134156-53-8
4-((((3aR,4R,6R,6aR)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 2 h / 110 °C / Inert atmosphere; Microwave irradiation

2: potassium hydrogenphosphate trihydrate; bromine / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere

With potassium hydrogenphosphate trihydrate; ammonia; bromine; In 1,4-dioxane; methanol; water;
DOI:10.1021/acs.jmedchem.9b01709