6-Bromo-5-hydroxypicolinic acid

Base Information

Chemical Name:6-Bromo-5-hydroxypicolinic acid
CAS No.:178876-92-1
Molecular Formula:C₆H₄BrNO₃
Molecular Weight:218.007
Hs Code.:
DSSTox Substance ID:DTXSID70587499
Wikidata:Q82479946
Mol file:178876-92-1.mol

Synonyms:6-Bromo-5-hydroxypicolinic acid;178876-92-1;6-bromo-5-hydroxypyridine-2-carboxylic acid;6-bromo-5-hydroxy-2-pyridinecarboxylic acid;SCHEMBL934791;6-Bromo-5-hydroxypicolinicacid;DTXSID70587499;DB-065236;CS-0328486;AR-011/43409547

Suppliers and Price of 6-Bromo-5-hydroxypicolinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Bromo-5-hydroxypicolinicacid 95+%
1g
$ 608.00

Chemenu
6-bromo-5-hydroxypicolinicacid 95%
1g
$ 574.00

Chemcia Scientific
6-Bromo-5-hydroxy-pyridine-2-carboxylicacid 95%
0.5 G
$ 295.00

American Custom Chemicals Corporation
6-BROMO-5-HYDROXY-2-PYRIDINECARBOXYLIC ACID 95.00%
5MG
$ 505.52

American Custom Chemicals Corporation
6-BROMO-5-HYDROXY-2-PYRIDINECARBOXYLIC ACID 95.00%
1G
$ 2202.90

Alichem
6-Bromo-5-hydroxypicolinicacid
250mg
$ 1009.40

Total 5 raw suppliers

Chemical Property of 6-Bromo-5-hydroxypicolinic acid

Chemical Property:

Boiling Point:486.9±45.0 °C(Predicted)
PKA:3.50±0.10(Predicted)
PSA：70.42000
Density:1.985±0.06 g/cm3(Predicted)
LogP:1.24790
Storage Temp.:2-8°C
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:216.93746
Heavy Atom Count:11
Complexity:164

Purity/Quality:

95+% ^*data from raw suppliers

6-Bromo-5-hydroxypicolinicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC(=C1O)Br)C(=O)O

Technology Process of 6-Bromo-5-hydroxypicolinic acid

There total 5 articles about 6-Bromo-5-hydroxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 170235-18-4
methyl 2-bromo-3-methoxy-6-pyridinecarboxylic acid

: 178876-92-1
6-Bromo-5-hydroxy-pyridine-2-carboxylic acid

Guidance literature:: With aluminium trichloride; sodium chloride; at 150 ℃; for 0.0333333h;
DOI:10.1021/jo960433d

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 178876-92-1
6-Bromo-5-hydroxy-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / pyridine / 77 h / Ambient temperature

2: 88 percent / K₂CO₃ / acetone / Heating

3: 77 percent / KMnO₄ / H₂O / 3 h / 90 °C

4: Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

5: 98 percent / AlCl₃, NaCl / 0.03 h / 150 °C

With dmap; potassium permanganate; aluminium trichloride; bromine; potassium carbonate; triethylamine; sodium chloride; In pyridine; dichloromethane; water; acetone;
DOI:10.1021/jo960433d

Reference yield:

: 24207-22-5
2-bromo-3-methoxy-6-methyl-pyridine

: 178876-92-1
6-Bromo-5-hydroxy-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / KMnO₄ / H₂O / 3 h / 90 °C

2: Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

3: 98 percent / AlCl₃, NaCl / 0.03 h / 150 °C

With dmap; potassium permanganate; aluminium trichloride; triethylamine; sodium chloride; In dichloromethane; water;
DOI:10.1021/jo960433d