Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate

Base Information

Chemical Name:Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate
CAS No.:170235-19-5
Molecular Formula:C7H6BrNO3
Molecular Weight:232.034
Hs Code.:2933399090
European Community (EC) Number:875-623-1
DSSTox Substance ID:DTXSID00570955
Wikidata:Q82458533
Mol file:170235-19-5.mol

Synonyms:170235-19-5;methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate;Methyl 6-bromo-5-hydroxypicolinate;METHYL 6-BROMO-5-HYDROXYPYRIDINE-2-CARBOXYLATE;MFCD09878491;2-Pyridinecarboxylic acid, 6-bromo-5-hydroxy-, methyl ester;SCHEMBL544568;DTXSID00570955;GAVHSGPZDJCNDR-UHFFFAOYSA-N;Methyl6-bromo-5-hydroxypicolinate;CS-B1159;VGA23519;AKOS022175339;AS-66876;SY261104;Methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate;methyl 2-bromo-3-hydroxy-6-pyridine carboxylate;methyl 6-bromo-5-hydroxy-2-pyridine carboxylate;methyl 6-bromo-5-hydroxy-2-pyridine-carboxylate;A882035;AP-501/43409548;J-522537

Suppliers and Price of Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
methyl 6-bromo-5-hydroxypyridine-2-carboxylate 95
1g
$ 492.00

Labseeker
methyl 6-bromo-5-hydroxypyridine-2-carboxylate 95
5g
$ 846.00

Crysdot
Methyl6-bromo-5-hydroxypicolinate 95+%
250mg
$ 232.00

Crysdot
Methyl6-bromo-5-hydroxypicolinate 95+%
1g
$ 580.00

Chemenu
Methyl6-bromo-5-hydroxypicolinate 95%
1g
$ 542.00

Chemcia Scientific
6-Bromo-5-hydroxy-pyridine-2-carboxylicacidmethylester 95%
2.5 G
$ 1190.00

American Custom Chemicals Corporation
METHYL-6-BROMO-5-HYDROXY-2-PYRIDINECARBOXYLATE 95.00%
250MG
$ 425.25

Alichem
Methyl6-bromo-5-hydroxypicolinate
1g
$ 653.20

Alichem
Methyl6-bromo-5-hydroxypicolinate
250mg
$ 261.28

Total 13 raw suppliers

Chemical Property of Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate

Chemical Property:

Vapor Pressure:2.43E-07mmHg at 25°C
Boiling Point:411°C at 760 mmHg
PKA:3.46±0.10(Predicted)
Flash Point:202.4°C
PSA：59.42000
Density:1.716g/cm³
LogP:1.33630
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:230.95311
Heavy Atom Count:12
Complexity:176

Purity/Quality:

97% ^*data from raw suppliers

methyl 6-bromo-5-hydroxypyridine-2-carboxylate 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=NC(=C(C=C1)O)Br

Technology Process of Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate

There total 6 articles about Methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 170235-18-4
methyl 2-bromo-3-methoxy-6-pyridinecarboxylic acid

: 170235-19-5
methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate

Guidance literature:: With aluminium trichloride; In dichloromethane; for 50h; Heating;
DOI:10.1016/00404-0399(50)1024C-

Reference yield: 56.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 178876-92-1
6-Bromo-5-hydroxy-pyridine-2-carboxylic acid

: 170235-19-5
methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate

: 170235-18-4
methyl 2-bromo-3-methoxy-6-pyridinecarboxylic acid

Guidance literature:: In diethyl ether; at 0 ℃;
DOI:10.1021/jo960433d

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 170235-19-5
methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / pyridine / 77 h / Ambient temperature

2: 88 percent / K₂CO₃ / acetone / Heating

3: 77 percent / KMnO₄ / H₂O / 3 h / 90 °C

4: Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

5: 93 percent / AlCl₃ / CH₂Cl₂ / 48 h / Heating

With dmap; potassium permanganate; aluminium trichloride; bromine; potassium carbonate; triethylamine; In pyridine; dichloromethane; water; acetone;
DOI:10.1021/jo960433d