170235-18-4

Usage

Uses

Used in Pharmaceutical Research:
2-Pyridinecarboxylic acid, 6-bromo-5-methoxy-, methyl ester is used as a research compound for its potential role in the development of new drug candidates. Its unique structure and properties contribute to the exploration of its therapeutic benefits and possible applications in medicine.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Pyridinecarboxylic acid, 6-bromo-5-methoxy-, methyl ester is used as a precursor. It serves as a starting material for the synthesis of various biologically active compounds, highlighting its importance in the creation of molecules with potential applications in different areas of science and medicine.
Used in the Development of Biologically Active Compounds:
2-Pyridinecarboxylic acid, 6-bromo-5-methoxy-, methyl ester is utilized as a key component in the synthesis of biologically active compounds. Its presence in these compounds can lead to the discovery of new therapeutic agents, further expanding the scope of its applications in the pharmaceutical industry.

Upstream product

• 54232-43-8 6-bromo-5-methoxy-2-pyridinecarboxylic acid 
• 79-22-1 methyl chloroformate 
• 186581-53-3 diazomethane 
• 178876-92-1 6-Bromo-5-hydroxy-pyridine-2-carboxylic acid 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 67-56-1 methanol 
• 23003-35-2 2-bromo-3-hydroxy-6-methylpyridine 
• 24207-22-5 2-bromo-3-methoxy-6-methyl-pyridine 

Downstream Products

• 170235-19-5 methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate 
• 178876-92-1 6-Bromo-5-hydroxy-pyridine-2-carboxylic acid 
• 219498-91-6 5-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid methyl ester 
• 1610625-66-5 N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine 
• 1610625-65-4 N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-(methoxycarbonyl)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine 
• 1610625-64-3 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid 6-methyl ester 
• 1610625-63-2 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

3-HYDROXY-2-PHENYL-6-(PYRAZOL-4-YLMETHYL)PYRIDINE DERIVATIVES AS PDE4D INHIBITORS

Provided herein are phosphodiesterase 4D (PDE4D) inhibitors of Formula (I), including methods of using the same. Also provided are methods of treating subjects suffering from conditions associated with aberrant PDE activity, in particular Fragile X syndrome, Alzheimer's disease, memory loss, cognitive dysfunction, autistic spectrum disorder, Parkinson's disease, major depression, bipolar disorder, schizophrenia, multiple sclerosis, traumatic brain injury, or chronic traumatic encephalopathy. Formula (I), wherein, R1 is H, C1-6alkyl, or C1-6haloalkyl; R2 is H, C1-3alkyl, or C1-3haloalkyl; R3 and R4 are each H or D, and at least one of R3 and R4 is D; each R5 is independently halo, CN, OH, NO2, C1-6alkoxy, C1-6haloalkoxy, C1-6alkyl, C1-6haloalkyl, O-C3-6cycloalkyl, C1-6hydroxyalkyl, or SO2C1-3alkyl; X and Y are each independently CR6 or N; each R6 is independently H, C1-3alkyl, or C1-3haloalkyl; and n is 0, 1, 2, 3, or 4.

DI-MACROCYCLES

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

Total synthesis of dimethyl sulfomycinamate

Dimethyl sulfomycinamate (1), a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chemistry of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined. The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on doubly activated pyridine 62 and the condensation reaction between bromo ketone 69 and amide 28 to form the oxazole moiety 76. The first preparation of oxazole triflates is described, as are some of their chemical properties.

Total synthesis of dimethyl sulfomycinamate

The first total synthesis of dimethyl sulfomycinamate (1) is described. Highlights of the synthesis include a selective palladium-catalyzed coupling reaction on the bromotriflate 21, and a condensation reaction to form the oxazole ring.