2-Naphthohydroxamic acid, O-acetate ester

Base Information

• Chemical Name: 2-Naphthohydroxamic acid, O-acetate ester
• CAS No.: 76749-37-6
• Molecular Formula: C13H11 N O3
• Molecular Weight: 229.23
• Mol file: 76749-37-6.mol

Synonyms:2-Naphthalenecarboxamide,N-(acetyloxy)- (9CI)

Chemical Property of 2-Naphthohydroxamic acid, O-acetate ester

Chemical Property:

• Refractive Index: 1.5500 (estimate)
• Boiling Point: 371.13°C (rough estimate)
• PSA: 55.40000
• Density: 1.246g/cm³
• LogP: 2.43860

Purity/Quality:

99% ^*data from raw suppliers

2-NAPHTHOHYDROXAMIC ACID-O-ACETATE ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthohydroxamic acid, O-acetate ester

There total 2 articles about 2-Naphthohydroxamic acid, O-acetate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

naphthalene-2-carboxylic acid hydroxyamide (10335-79-2) + acetic anhydride (108-24-7) → C13H11NO3 (76749-37-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; Alkaline conditions;

DOI:10.1039/c4ob00512k

Reference yield:

2-naphthaloyl chloride (2243-83-6) → C13H11NO3 (76749-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water; tetrahydrofuran / 20 °C

2: tetrahydrofuran / 20 °C / Alkaline conditions

With hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1039/c4ob00512k

Reference yield: 50.0%

C13H11NO3 (76749-37-6) + (3,3-dimethylcycloprop-1-en-1-yl)-(phenyl)methanol → trans-3-(3-benzoyl-2,2-dimethylcyclopropyl)-2-naphthamide

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; caesium carbonate; In acetonitrile; at 40 ℃; for 24h; diastereoselective reaction;

DOI:10.1021/acs.orglett.9b04608

upstream raw materials:

2-naphthaloyl chloride

naphthalene-2-carboxylic acid hydroxyamide

acetic anhydride

Refernces

• 1、 Lam, Hon-Wah,Man, Ka-Yi,Chan, Wai-Wing,Zhou, Zhongyuan,Yu, Wing-Yiu. "Rhodium(iii)-catalyzed formal oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters. A facile synthesis of functionalized benzolactams". . p. 4112 - 4116. Retrieved 2014/06/10.