10335-79-2

Basic information

• Product Name: N,N-naphthaloylhydroxylamine
• Synonyms: N,N-naphthaloylhydroxylamine;2-NAPHTHOHYDROXAMICACID;2-Naphthalenecarbohydroximic acid;N-Hydroxy-2-naphthalenecarboxamide
• CAS NO: 10335-79-2
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.21
• Mol File: 10335-79-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 168°C
• Boiling Point: 321.94°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.1963 (rough estimate)
• Refractive Index: 1.4900 (estimate)
• CAS DataBase Reference: N,N-naphthaloylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-naphthaloylhydroxylamine(10335-79-2)
• EPA Substance Registry System: N,N-naphthaloylhydroxylamine(10335-79-2)

Safety Data

• Hazardous Substances Data: 10335-79-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9NO2/c13-11(12-14)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,14H,(H,12,13)

Upstream product

• 93-09-4 naphthalene-2-carboxylate 
• 2243-83-6 2-naphthaloyl chloride 
• 2459-25-8 methyl naphthalene-2-carboxylate 
• 141903-34-6 N-(2'-naphthoyl)imidazole 

Downstream Products

• 2243-54-1 2-naphthylisocyanate 
• 80-05-7 BPA 
• 1600529-79-0 N-(2-formylphenyl)-2-naphthamide 
• 1360651-40-6 3,4-diphenylbenzo[g]isoquinolin-1(2H)-one 
• 76749-37-6 C₁₃H₁₁NO₃ 

Relevant articles and documents

Silver-Catalyzed Acyl Nitrene Transfer Reactions Involving Dioxazolones: Direct Assembly of N-Acylureas

Dioxazolones and isocyanides are useful synthetic building blocks, and have attracted significant attention from researchers. However, the silver-catalyzed nitrene transfer reaction of dioxazolones has not been investigated to date. Herein, a silver-catalyzed acyl nitrene transfer reaction involving dioxazolones, isocyanides, and water was realized in the presence of Ag2O to afford a series of N-acylureas in moderate to good yields.

Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones

An cascade intramolecular 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, phenyl hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones using unexpensive Pd(PPh3)4 as catalyst has been developed. The protocol enables the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields. (Figure presented.).

Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives

An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines via sequential palladium-catalyzed decarboxylative amination/intramolecular 6-endo-dig benzannulation reactions has been described. In this reaction, a broad range of electron-rich, electron-neutral, and electron-deficient o-alkynylarylketones react well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method.