3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER
• CAS No.: 191287-06-6
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.30616
• Mol file: 191287-06-6.mol

Synonyms:3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER

Chemical Property of 3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER

Chemical Property:

• PSA: 52.32000
• LogP: 3.68430

Purity/Quality:

99%min ^*data from raw suppliers

Methyl3-amino-4-cyclohexylbenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER

There total 3 articles about 3-AMINO-4-CYCLOHEXYL-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-cyclohexyl-3-nitrobenzoic acid methyl ester (191287-05-5) → 3-amino-4-cyclohexylbenzoic acid methyl ester (191287-06-6)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 6h; Heating;

DOI:10.1080/00397919708006827

Reference yield:

4-cyclohexylbenzoic acid (20029-52-1) → 3-amino-4-cyclohexylbenzoic acid methyl ester (191287-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / conc. H₂SO₄ / 15 h / Heating

2: 97 percent / conc. H₂SO₄, conc. HNO₃ / 0.5 h / 0 °C

3: 91 percent / HCO₂NH₄ / Pd/C / methanol / 6 h / Heating

With sulfuric acid; nitric acid; ammonium formate; palladium on activated charcoal; In methanol;

DOI:10.1080/00397919708006827

Reference yield:

4-cyclohexylbenzoic acid methyl ester (92863-34-8) → 3-amino-4-cyclohexylbenzoic acid methyl ester (191287-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / conc. H₂SO₄, conc. HNO₃ / 0.5 h / 0 °C

2: 91 percent / HCO₂NH₄ / Pd/C / methanol / 6 h / Heating

With sulfuric acid; nitric acid; ammonium formate; palladium on activated charcoal; In methanol;

DOI:10.1080/00397919708006827

upstream raw materials:

4-cyclohexyl-3-nitrobenzoic acid methyl ester

4-cyclohexylbenzoic acid

4-cyclohexylbenzoic acid methyl ester

Downstream raw materials:

3-chloro-4-cyclohexyl-benzyl alcohol

3-chloro-4-cyclohexylbenzaldehyde

3-chloro-4-cyclohexyl-benzoic acid methyl ester

Refernces