3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione

Base Information

Chemical Name:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione
CAS No.:1256245-82-5
Molecular Formula:C31H26F6N4O2
Molecular Weight:600.5541592
Hs Code.:
Mol file:1256245-82-5.mol

Synonyms:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione

Suppliers and Price of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione

Chemical Property:

Melting Point:181-183 °C (decomp)
Boiling Point:618.2±65.0 °C(Predicted)
PKA:9.30±0.70(Predicted)
PSA：74.33000
Density:1.44±0.1 g/cm3(Predicted)
LogP:6.67680

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione

There total 3 articles about 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[(9R)-cinchonan-9-ylaMino]-3-Cyclobutene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1223105-85-8
3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

: 9-amino-9-deoxyepicinchonine

: 1256245-82-5
C₃₁H₂₆F₆N₄O₂

Guidance literature:: In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/ol102294g

Reference yield:

: 1223105-85-8
3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

: (8R,9R)-9-amino(9-deoxy)epicinchonin

: 1256245-82-5
C₃₁H₂₆F₆N₄O₂

Guidance literature:: In dichloromethane; for 18h; Reflux;
DOI:10.1016/j.tet.2021.132381

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1256245-82-5
C₃₁H₂₆F₆N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: dichloromethane / 18 h / Reflux

In methanol; dichloromethane;
DOI:10.1016/j.tet.2021.132381