Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Base Information

Chemical Name:Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate
CAS No.:54023-09-5
Molecular Formula:C₁₃H₉F₃O₃
Molecular Weight:270.208
Hs Code.:
DSSTox Substance ID:DTXSID30699446

Synonyms:54023-09-5;Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate;methyl 5-[3-(trifluoromethyl)phenyl]furan-2-carboxylate;SCHEMBL1199181;DTXSID30699446;WEDHIJOMWBZOLH-UHFFFAOYSA-N

Suppliers and Price of Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:270.05037863
Heavy Atom Count:19
Complexity:330

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC=C(O1)C2=CC(=CC=C2)C(F)(F)F

Technology Process of Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

There total 5 articles about Methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2527-99-3
methyl 5-bromo-2-furoate

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 54023-09-5
methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2020.112669

Reference yield: 69.0%

: 611-13-2
2-furoic acid methyl ester

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 54023-09-5
methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Guidance literature:: With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 130 ℃; for 20h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101102

Reference yield: 45.0%

: 611-13-2
2-furoic acid methyl ester

: 98-16-8
3-trifluoromethylaniline

: 54023-09-5
methyl 5-(3-(trifluoromethyl)phenyl)furan-2-carboxylate

Guidance literature:: 3-trifluoromethylaniline; With hydrogenchloride; sodium nitrite;

2-furoic acid methyl ester; With copper(II) chloride dihydrate; In water; acetone; at 0 - 30 ℃;
DOI:10.1134/S1070428009040125