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Minocycline hydrochloride

Base Information Edit
  • Chemical Name:Minocycline hydrochloride
  • CAS No.:13614-98-7
  • Molecular Formula:C23H27N3O7.ClH
  • Molecular Weight:493.944
  • Hs Code.:29413020
  • Mol file:13614-98-7.mol
Minocycline hydrochloride

Synonyms:2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride, (4S,4aS,5aR,12aS)- (9CI);2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,12aa)]-;Acnez;Klinomycin;Minocin;Minocyclinehydrochloride;Minomycin;NSC 141993;Periocline;Vectrin;Minocycline HCL;2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aR,12aS)-;

Suppliers and Price of Minocycline hydrochloride
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Minocycline Hydrochloride
  • 100mg
  • $ 65.00
  • TRC
  • Minocycline Hydrochloride
  • 25mg
  • $ 50.00
  • Tocris
  • Minocycline Hydrochloride ≥98%(HPLC)
  • 50
  • $ 108.00
  • TCI Chemical
  • Minocycline Hydrochloride >98.0%(HPLC)(T)
  • 5g
  • $ 469.00
  • TCI Chemical
  • Minocycline Hydrochloride >98.0%(HPLC)(T)
  • 1g
  • $ 138.00
  • Sigma-Aldrich
  • Minocycline hydrochloride powder
  • 25mg
  • $ 33.80
  • Sigma-Aldrich
  • Minocycline, Hydrochloride
  • 50mg
  • $ 64.19
  • Sigma-Aldrich
  • Minocycline hydrochloride powder
  • 100mg
  • $ 90.30
  • Sigma-Aldrich
  • Minocycline hydrochloride powder
  • 250mg
  • $ 150.00
  • Sigma-Aldrich
  • Minocycline hydrochloride United States Pharmacopeia (USP) Reference Standard
  • 350mg
  • $ 366.00
Total 206 raw suppliers
Chemical Property of Minocycline hydrochloride Edit
Chemical Property:
  • Appearance/Colour:crystalline yellow powder 
  • Vapor Pressure:6.33E-28mmHg at 25°C 
  • Melting Point:205-210 °C(dec) 
  • Boiling Point:812.8 °C at 760 mmHg 
  • Flash Point:445.4 °C 
  • PSA:164.63000 
  • LogP:1.68890 
  • Storage Temp.:2-8°C 
  • Solubility.:Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates. 
  • Water Solubility.:Freely soluble in water 
Purity/Quality:

99.9% *data from raw suppliers

Minocycline Hydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36 
MSDS Files:

SDS file from LookChem

Useful:
  • Description Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model.1 Reduces MMP-9 activity.2 Attenuates disease severity in mouse models of multiple sclerosis.3 Displays neuroprotective activity.4 Minocycline HCl may be effective in methotrexate-induced lung fibrosis.5?Orally active and brain penetrant.
  • Uses Second generation tetracycline antibiotic. Antibacterial. antiinflammatory Minocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
  • Therapeutic Function Antibiotic
Technology Process of Minocycline hydrochloride

There total 9 articles about Minocycline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; In ethanol; at 0 - 5 ℃; for 1h; pH=1 - 2; Solvent;
Guidance literature:
With hydrogenchloride; palladium on activated carbon; hydrogen; In methanol; water; at 25 ℃; for 7h; under 6000.6 Torr; Autoclave;
Guidance literature:
O-benzoyl N,N-dimethylhydroxylamine; C24H26N2O9; With iron(III) chloride; In toluene; at 20 ℃; for 2h; Inert atmosphere;
With hydrogenchloride; In water; for 0.5h;
Refernces Edit
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