DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate

Base Information

Chemical Name:DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate
CAS No.:934843-29-5
Molecular Formula:C₂₂H₁₇ClF₃NO₅
Molecular Weight:467.829
Hs Code.:
Mol file:934843-29-5.mol

Synonyms:DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate

Suppliers and Price of DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate

Chemical Property:

PSA：74.60000
LogP:4.50670

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate

There total 6 articles about DiMethyl 2-((1-(4-chlorobenzoyl)-2-(trifluoroMethyl)-1H-indo-l-3-yl)Methyl)Malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 929075-62-7
[3-(bromomethyl)-2-(trifluoromethyl)-1H-indol-1-yl](4-chlorophenyl)methanone

: 108-59-8
malonic acid dimethyl ester

: 934843-29-5
dimethyl-2-{[1-(4-chlorobenzoyl)-2-(trifluoromethyl)indol-3-yl]methyl}malonate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;
DOI:10.1055/s-2007-967950

Reference yield:

: 913962-14-8
N-[2-(1-bromoethyl)phenyl]-2,2,2-trifluoroacetimidoyl chloride

: 934843-29-5
dimethyl-2-{[1-(4-chlorobenzoyl)-2-(trifluoromethyl)indol-3-yl]methyl}malonate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / magnesium / tetrahydrofuran / 2 h / 0 °C

2: 93 percent / NaH; Me₂SO / various solvent(s); tetrahydrofuran / 2 h / 20 °C

3: 85 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / 5 h / Heating

4: 89 percent / t-BuOK / tetrahydrofuran / 4 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; sodium hydride; magnesium; dimethyl sulfoxide; In tetrahydrofuran; tetrachloromethane; 1: Grignard cyclization reaction;
DOI:10.1016/j.jfluchem.2007.04.023

Reference yield:

: 913955-35-8
3-methyl-2-(trifluoromethyl)-1H-indole

: 934843-29-5
dimethyl-2-{[1-(4-chlorobenzoyl)-2-(trifluoromethyl)indol-3-yl]methyl}malonate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaH; Me₂SO / various solvent(s); tetrahydrofuran / 2 h / 20 °C

2: 85 percent / N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / 5 h / Heating

3: 89 percent / t-BuOK / tetrahydrofuran / 4 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1016/j.jfluchem.2007.04.023