Telmisartan Amide

Base Information

• Chemical Name: Telmisartan Amide
• CAS No.: 915124-86-6
• Molecular Formula: C33H31N5O
• Molecular Weight: 513.642
• UNII: 0C9IQ6NHUX
• DSSTox Substance ID: DTXSID00238604
• Nikkaji Number: J3.348.758D
• Wikidata: Q27236607
• ChEMBL ID: CHEMBL4785781
• Mol file: 915124-86-6.mol

Synonyms:Telmisartan Amide;915124-86-6;UNII-0C9IQ6NHUX;0C9IQ6NHUX;Telmisartan EP Impurity F;Telmisartan impurity F [EP];CHEMBL4785781;Telmisartan impurity, telmisartan amide- [USP];(1,1'-Biphenyl)-2-carboxamide, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-;4'-((4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl)methyl)biphenyl-2-carboxamide;2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzamide;SCHEMBL2039420;DTXSID00238604;BDBM50564377;CS-O-08262;HY-146480;CS-0499091;FT-0674838;TELMISARTAN IMPURITY F [EP IMPURITY];A1-01719;Q27236607;TELMISARTAN IMPURITY, TELMISARTAN AMIDE- [USP IMPURITY];4'-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)biphenyl-2-carboxamide;4'-(1,4'-Dimethyl-2'-propyl-2,6'-bi[1H-benzoimidazole]-1'-ylmethyl)biphenyl-2-carboxamide;4?-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl][1,1?-biphenyl]-2-carboxamide (Telmisartan Amide)

Chemical Property of Telmisartan Amide

Chemical Property:

• PSA: 79.72000
• LogP: 7.54930
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 513.25286063
• Heavy Atom Count: 39
• Complexity: 829

Purity/Quality:

99% ^*data from raw suppliers

TelmisartanAmide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)N)C=C(C=C2C)C5=NC6=CC=CC=C6N5C
• Uses: An amide impurity of Temisartan (D294250).

Technology Process of Telmisartan Amide

There total 2 articles about Telmisartan Amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl (144702-27-2) → 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide (915124-86-6)

Guidance literature:

With sodium hydroxide; water; In ethanol; at 5 - 25 ℃; for 18h; Heating / reflux;

Reference yield: 17.0%

telmisatran (144701-48-4) → 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide (915124-86-6)

Guidance literature:

telmisatran; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

With ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16.5h;

DOI:10.1016/j.ejmech.2020.112258

Reference yield: 89.0%

4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide (915124-86-6) → telmisatran (144701-48-4)

Guidance literature:

4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide; With sulfuric acid; In water; at 125 ℃; for 28h;

With sodium hydroxide; In dichloromethane; water; pH=5.4;

upstream raw materials:

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl

telmisatran

Downstream raw materials:

telmisatran