144702-27-2

Basic information

• Product Name: propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-
• Synonyms: [1,1'-Biphenyl]-2-carbonitrile,4'-[[1,4'-dimethyl-2'-;propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-;2-Descarboxy-2-cyano TelMisartan;4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-1H-benziMidazol]-1'-yl)Methyl]-[1,1'-biphenyl]-2-carbonitrile;TelMisartan IMpurity G;TelMisartan EP IMpurity G;[1,1'-Biphenyl]-2-carbonitrile, 4'-[(1,4'-diMethyl-2'-propyl[2,6'-bi-1H-benziMidazol]-1'-yl) Methyl]-;[1,1'-Biphenyl]-2-carbonitrile,4'-[(1,4'-dimethyl -2'-propyl [2,6”-bi
• CAS NO: 144702-27-2
• Molecular Formula: C₃₃H₂₉N₅
• Molecular Weight: 495.61686
• EINECS: 1592732-453-0
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 144702-27-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 181.2-182.1℃
• Boiling Point: 775.1±70.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: 4.99±0.10(Predicted)
• Water Solubility: 6μg/L at 20℃
• CAS DataBase Reference: propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-(144702-27-2)
• EPA Substance Registry System: propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]-(144702-27-2)

Safety Data

• Hazardous Substances Data: 144702-27-2(Hazardous Substances Data)

Usage

Uses

2-Descarboxy-2-cyano Telmisartan is an impurity of the angiotensin II receptor antagonist, Telmisartan (T017000).

Upstream product

• 860787-42-4 4-amino-3-bromo-5-methylbenzoic acid 
• 152628-01-8 4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester 
• 675882-71-0 3-methyl-4-butyrylamino-5-aminobenzoic acid methyl ester 
• 152628-00-7 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester 
• 1098100-86-7 2-cyano-4'-[2-n-propyl-4-methyl-6-methylcarboxylate-benzimidazole-1-ylmethyl]biphenyl 
• 136304-93-3 4-(2'-cyanophenyl)benzyl chloride 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 1098100-87-8 2-cyano-4'-[2-n-propyl-4-methyl-6-carboxylate-benzimidazole-1-ylmethyl]biphenyl 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 1098100-91-4 4'-((N,7-dimethyl-N-(2-aminophenyl)-2-propyl-3H-benzo[d]imidazole-5-carboxamide-3-yI)-methyl)-biphenyl-2-nitrile 
• 1098100-88-9 7-methyl-N-(2-methylamino)-phenyl-2-propyl-3-(2'-cyano-4-ylmethylbiphenyl)-3H-benzimidazole-5-carboxamide 
• 1098100-85-6 N-((2-cyano-biphenyl-4'-methyl)amino-6-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)phenyl)butyramide 

Downstream Products

• 1100995-38-7 4'-{[2-n-propyl-4-methyl-6-(1-methylbenzoimidazol-2-yl)benzoimidazol-1-yl]methyl}-2-(1H-imidazoline-2-yl)biphenyl 
• 960356-45-0 telmisartan meglumine salt 
• 960356-41-6 telmisartan choline salt 
• 960356-49-4 telmisartan tris-(hydroxymethyl)amine salt 
• 960356-46-1 telmisartan ethanolamine salt 
• 960356-48-3 telmisartan diethylamine salt 
• 862286-67-7 telmisartan tert-butylamine salt 
• 960356-44-9 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt 
• 915124-86-6 4’-((1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxamide 
• 515815-48-2 tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride 
• 144701-48-4 telmisatran 

Relevant articles and documents

Compound based on benzimidazole substituted halogenated phenyl n-butylamidine and preparation method of compound

The invention relates to a compound based on benzimidazole substituted halogenated phenyl n-butylamidine as shown in a formula II and a preparation method thereof. According to the method disclosed by the invention, nitrification and polyphosphoric acid cyclization reactions are avoided, and the generation of a large amount of waste acid reaction liquid is avoided from the source.

Method for preparing telmisartan and intermediates thereof

Disclosed is a telmisartan preparation method, characterized in that: 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl) benzimidazole (compound I) and 4'-halomethyl diphenyl-2-substituted compound (compound II) conduct a nucleophilic substitution reaction to obtain a compound III; when R is COOH, the compound III is telmisartan; and when R is COOR' or CN, the compound III can be hydrolyzed to obtain telmisartan.

ONE POT PROCESS FOR THE PREPARATION OF TELMISARTAN

A process for the preparation of bromine free telmisartan in one pot starting from 2-cyano-4'- methyl biphenyl, a compound of the Formula (1). The compound of the Formula (1) is chlorinated to give 4-chloromethyl-2' -cyanobiphenyl, the compound of the Formula (2). The reaction of the compound of the Formula (2), with 2-n-propyl-4-methyl-6-(1'- methylbenzimidazol-2'-yl) benzimidazole, a compound of the Formula (3) yields the compound 2-cyano-4'-[2"-n-propyl-4"-methyl-6"-(1'"-methylbenzimidazol-2"'- yl) benzimidazol-1"- ylmethyl] biphenyl, a compound of the Formula (4) which on hydrolysis of the cyano group yields telmisartan a compound of the Formula (5).