Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]-

Base Information

• Chemical Name: Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]-
• CAS No.: 1151800-43-9
• Molecular Formula: C15H8ClF2N5
• Molecular Weight: 331.712
• Mol file: 1151800-43-9.mol

Synonyms:Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]-

Chemical Property of Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]-

Chemical Property:

• PSA: 55.97000
• Density: 1.57±0.1 g/cm3(Predicted)
• LogP: 3.46600

Purity/Quality:

97% ^*data from raw suppliers

6-((6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)quinoline 97% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

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Technology Process of Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]-

There total 4 articles about Quinoline, 6-[(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)difluoromethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3,6-dichlorpyridazine (141-30-0) + 2,2-difluoro-2-(quinolin-6-yl)acetic acid hydrazide (943541-39-7) → 6-[(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-difluoro-methyl]-quinoline (1151800-43-9)

Guidance literature:

In butan-1-ol; at 130 ℃; for 12h;

Reference yield:

ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate (943541-40-0) → 6-[(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-difluoro-methyl]-quinoline (1151800-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 0.5 h / 45 °C

2: butan-1-ol / 12 h / 130 °C

With hydrazine hydrate; In methanol; butan-1-ol;

Reference yield:

6-bromoquinoline (5332-25-2) → 6-[(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-difluoro-methyl]-quinoline (1151800-43-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: copper / dimethyl sulfoxide / 15 h / 55 °C / Inert atmosphere

3: hydrazine hydrate / methanol / 0.5 h / 45 °C

4: butan-1-ol / 12 h / 130 °C

With copper(l) iodide; copper; hydrazine hydrate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; sodium iodide; In 1,4-dioxane; methanol; dimethyl sulfoxide; butan-1-ol;

upstream raw materials:

3,6-dichlorpyridazine

2,2-difluoro-2-(quinolin-6-yl)acetic acid hydrazide

6-bromoquinoline

6-iodoquinoline

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