NA

Base Information

• Chemical Name: NA
• CAS No.: 13626-20-5
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol file: 13626-20-5.mol

Synonyms:

Chemical Property of NA

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NA

There total 19 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperidine (110-89-4) + styrene oxide (96-09-3) → 1-phenyl-2-(piperidin-1-yl)ethan-1-ol (13626-20-5,40116-77-6,83829-03-2,2480-56-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 15 min; 25 deg C, 45 min, 2.) 25 deg C, 3 h;

DOI:10.1021/jo00104a034

Reference yield: 90.0%

1-(phenylglyoxylyl)piperidine (14377-63-0) → 1-phenyl-2-(piperidin-1-yl)ethan-1-ol (13626-20-5,40116-77-6,83829-03-2,2480-56-0)

Guidance literature:

1-(phenylglyoxylyl)piperidine; With diphenylsilane; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; for 0.166667h;

DOI:10.1039/c4ra13090a

Reference yield: 88.0%

1-phenyl-2-piperidin-1-yl-ethanone (779-52-2) → 1-phenyl-2-(piperidin-1-yl)ethan-1-ol (13626-20-5,40116-77-6,83829-03-2,2480-56-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1071/CH9810383

upstream raw materials:

piperidine

styrene oxide

ethanol

1-phenyl-2-piperidin-1-yl-ethanone

Downstream raw materials:

o-toluic acid-(1-phenyl-2-piperidino-ethyl ester); hydrochloride

2-ethoxy-benzoic acid-(1-phenyl-2-piperidino-ethyl ester); hydrochloride

carbamic acid-(1-phenyl-2-piperidino-ethyl ester)

4-cyclohexyl-butyric acid-(1-phenyl-2-piperidino-ethyl ester); hydrochloride