1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)

Base Information

• Chemical Name: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)
• CAS No.: 14377-63-0
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.268
• Mol file: 14377-63-0.mol

Synonyms:1-phenyl-2-piperidyl-ethane-1,2-dione;1-phenyl-2-(piperidin-1-yl)ethane-1,2-dione;1-phenyl-2-piperidin-1-yl-ethane-1,2-dione;1-piperidino-2-phenylethane-1,2-dione;1-(α-oxophenylacetyl)piperidine;

Chemical Property of 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)

Chemical Property:

• Melting Point: 107-108 °C
• Boiling Point: 343.0±25.0 °C(Predicted)
• PKA: -1.36±0.20(Predicted)
• PSA: 37.38000
• Density: 1.154±0.06 g/cm3(Predicted)
• LogP: 1.81970

Purity/Quality:

99% ^*data from raw suppliers

1-Phenyl-2-(piperidin-1-yl)ethane-1,2-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)

There total 89 articles about 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) + 2-phenoxy-1-phenylethanone (721-04-0) → 1-(phenylglyoxylyl)piperidine (14377-63-0) + phenol (108-95-2,27073-41-2)

Guidance literature:

With copper(l) iodide; oxygen; In toluene; at 70 ℃; under 760.051 Torr; Reagent/catalyst; Solvent; Temperature; Sealed tube;

DOI:10.1039/c3cc46912c

Reference yield: 84.0%

piperidin-1-yl benzoate (5542-49-4) + phenylacetylene (536-74-3) → 1-(phenylglyoxylyl)piperidine (14377-63-0) + N-benzoylpiperidine (776-75-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1039/c6ra15219h

Reference yield: 70.0%

piperidine (110-89-4) + 2-(3,4-dimethoxyphenoxy)-1-phenylethanone → 1-(phenylglyoxylyl)piperidine (14377-63-0) + 3,4-dimethoxyphenol (2033-89-8)

Guidance literature:

With copper(l) iodide; oxygen; In toluene; at 70 ℃; under 760.051 Torr; Sealed tube;

DOI:10.1039/c3cc46912c

upstream raw materials:

piperidine

phenylglyoxylic acid ethyl ester

bromobenzene

carbon monoxide

Downstream raw materials:

N-<α-(piperidinocarbonyl)benzylidene>trimethylsilylmethylamine

1,1,6,6-Tetraphenyl-hexa-2,4-diyne-1,6-diol; compound with 1-phenyl-2-piperidin-1-yl-ethane-1,2-dione

Biphenyl-2,2'-dicarboxylic acid bis-dicyclohexylamide; compound with 1-phenyl-2-piperidin-1-yl-ethane-1,2-dione

2-hydroxy-2-phenyl-1-(piperidin-1-yl)ethan-1-one