Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester

Base Information

Chemical Name:Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester
CAS No.:4935-01-7
Molecular Formula:C₆H₈O₂
Molecular Weight:112.128
Hs Code.:
DSSTox Substance ID:DTXSID70197774
Nikkaji Number:J748.014H
Wikidata:Q83070544
Mol file:4935-01-7.mol

Synonyms:4935-01-7;Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester;Bicyclo[1.1.0]butane-1-carboxcylic acid methyl ester;bicyclo[1.1.0]butane-1-carboxylic acid methyl ester;SCHEMBL11785043;DTXSID70197774

Suppliers and Price of Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester

Chemical Property:

Vapor Pressure:8.8mmHg at 25°C
Boiling Point:132.6°Cat760mmHg
Flash Point:24.7°C
PSA：26.30000
Density:1.329g/cm³
LogP:0.56940
XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:112.052429494
Heavy Atom Count:8
Complexity:145

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C12CC1C2

Technology Process of Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester

There total 9 articles about Bicyclo(1.1.0)butane-1-carboxcylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15963-46-9,177498-41-8,177498-42-9
3-chlorocyclobutanecarboxylic acid methyl ester

: 4935-01-7
methyl bicyclo<1.1.0>butane-1-carboxylate

Guidance literature:: With 2,5-di-tert-butyl-p-benzoquinone; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja00730a022

Reference yield:

: 4935-00-6
methyl 3-bromocyclobutanecarboxylate

: 4935-01-7
methyl bicyclo<1.1.0>butane-1-carboxylate

Guidance literature:: With 4-tert-Butylcatechol; sodium hydride; In diethyl ether;
DOI:10.1016/S0040-4020(01)98361-9

Reference yield:

: 4934-98-9
methylester of 3-benzyloxycyclobutane-1-carboxylic acid

: 4935-01-7
methyl bicyclo<1.1.0>butane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd / methanol

2: (i) PhSO₂Cl, Py, (ii) LiBr, acetone

3: NaH, 4-tert-butyl-benzene-1,2-diol / diethyl ether

With 4-tert-Butylcatechol; hydrogen; sodium hydride; palladium; In methanol; diethyl ether;
DOI:10.1016/S0040-4020(01)98361-9