4935-00-6 Usage
Uses
Used in Organic Synthesis:
Methyl 3-bromocyclobutane-1-carboxylate is used as a synthetic building block for introducing the cyclobutane ring structure into various chemical compounds. Its ability to form this ring is crucial for the creation of complex organic molecules with specific properties and functions.
Used in Pharmaceutical Production:
In the pharmaceutical industry, Methyl 3-bromocyclobutane-1-carboxylate is utilized as an intermediate in the synthesis of various drugs. Its presence in the production process aids in the development of new medications with unique therapeutic effects.
Used in Agrochemical Production:
Similarly, in agrochemicals, Methyl 3-broMocyclobutane-1-carboxylate is employed as an intermediate for the synthesis of various products. It contributes to the development of agrochemicals that can enhance crop protection and yield.
Used in Fine Chemicals Production:
Methyl 3-bromocyclobutane-1-carboxylate is also used in the production of fine chemicals, which are high-purity chemicals used in various industries, including the fragrance, flavor, and specialty chemical sectors. Its role in these processes is essential for achieving the desired purity and performance of the final products.
Safety Precautions:
Due to its moderate toxicity and potential to cause irritation, Methyl 3-bromocyclobutane-1-carboxylate should be handled with care. It is imperative to use proper protective equipment and ensure that the work area is well-ventilated to minimize health risks associated with exposure to Methyl 3-broMocyclobutane-1-carboxylate.
Check Digit Verification of cas no
The CAS Registry Mumber 4935-00-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,3 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4935-00:
(6*4)+(5*9)+(4*3)+(3*5)+(2*0)+(1*0)=96
96 % 10 = 6
So 4935-00-6 is a valid CAS Registry Number.
4935-00-6Relevant academic research and scientific papers
Bicyclobutane carboxylic amide as a cysteine-directed strained electrophile for selective targeting of proteins
Shindo, Naoya,Ojida, Akio,Tokunaga, Keisuke,Sato, Mami,Kuwata, Keiko,Miura, Chizuru,Fuchida, Hirokazu,Matsunaga, Naoya,Koyanagi, Satoru,Ohdo, Shigehiro
supporting information, p. 18522 - 18531 (2020/11/02)
Expanding the repertoire of electrophiles with unique reactivity features would facilitate the development of covalent inhibitors with desirable reactivity profiles. We herein introduce bicyclo[1.1.0]butane (BCB) carboxylic amide as a new class of thiol-reactive electrophiles for selective and irreversible inhibition of targeted proteins. We first streamlined the synthetic routes to generate a variety of BCB amides. The strain-driven nucleophilic addition to BCB amides proceeded chemoselectively with cysteine thiols under neutral aqueous conditions, the rate of which was significantly slower than that of acrylamide. This reactivity profile of BCB amide was successfully exploited to develop covalent ligands targeting Bruton's tyrosine kinase (BTK). By tuning BCB amide reactivity and optimizing its disposition on the ligand, we obtained a selective covalent inhibitor of BTK. The in-gel activitybased protein profiling and mass spectrometry-based chemical proteomics revealed that the selected BCB amide had a higher target selectivity for BTK in human cells than did a Michael acceptor probe. Further chemical proteomic study revealed that BTK probes bearing different classes of electrophiles exhibited distinct off-target profiles. This result suggests that incorporation of BCB amide as a cysteine-directed electrophile could expand the capability to develop covalent inhibitors with the desired proteome reactivity profile.
