4-Bromo-2-iodobenzaldehyde

Base Information

• Chemical Name: 4-Bromo-2-iodobenzaldehyde
• CAS No.: 1261470-87-4
• Molecular Formula: C7H4BrIO
• Molecular Weight: 310.917
• Hs Code.: 2913000090
• Mol file: 1261470-87-4.mol

Synonyms:4-Bromo-2-iodobenzaldehyde;4-Bromo-2-iodobenzaldehyde97%

Chemical Property of 4-Bromo-2-iodobenzaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 2.86620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-Iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-iodobenzaldehyde

There total 7 articles about 4-Bromo-2-iodobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromo-1-(bromomethyl)-2-iodobenzene (885681-96-9) → 5-bromo-1-iodo-2-benzaldehyde (1261470-87-4)

Guidance literature:

With 4-methylmorpholine N-oxide; In acetonitrile; at 0 - 20 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1021/jo2001726

Reference yield: 86.0%

(4-bromo-2-iodophenyl)methanol (1261438-69-0) → 5-bromo-1-iodo-2-benzaldehyde (1261470-87-4)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01881

Reference yield:

4-bromo-2-iodo-1-methylbenzene (260558-15-4) → 5-bromo-1-iodo-2-benzaldehyde (1261470-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / 1,2-dichloro-ethane / 5 h / Inert atmosphere; Reflux; Irradiation

2: 4-methylmorpholine N-oxide / acetonitrile / 0 - 20 °C / Inert atmosphere; Molecular sieve

With N-Bromosuccinimide; 4-methylmorpholine N-oxide; dibenzoyl peroxide; In 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jo2001726

upstream raw materials:

para-bromotoluene

4-bromo-2-iodo-1-methylbenzene

4-bromo-1-(bromomethyl)-2-iodobenzene

methyl 4-bromo-2-iodobenzoate

Downstream raw materials:

(Z)-1,2-bis(4-bromo-2-iodophenyl)ethene

(E)-N-(5-bromo-2-iodobenzylidene)-2-methylpropan-2-amine

Refernces

• 1、 Bello-Garciá, Jesús,Padín, Damián,Saá, Carlos,Varela, Jesús A.. "Nonplanar Tub-Shaped Benzocyclooctatetraenes via Halogen-Radical Ring Opening of Dihydrobiphenylenes". supporting information. p. 5539 - 5544. Retrieved 2021/07/26.
• 2、 Tang, Hai-Jun,Zhang, Yu-Feng,Jiang, Yi-Wen,Feng, Chao. "F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes". . p. 5190 - 5193. Retrieved 2018/09/12.