Tibolone 3-Ethylene Ketal

Base Information

• Chemical Name: Tibolone 3-Ethylene Ketal
• CAS No.: 677299-58-0
• Molecular Formula: C23H32O3
• Molecular Weight: 356.505
• Mol file: 677299-58-0.mol

Synonyms:Tibolone 3-Ethylene Ketal;(7α,17α)-17-Hydroxy-7-Methyl-19-norpregn-5(10)-en-20-yn-3-one Cyclic 1,2-Ethanediyl Acetal

Chemical Property of Tibolone 3-Ethylene Ketal

Chemical Property:

• PSA: 38.69000
• LogP: 4.05660

Purity/Quality:

97% ^*data from raw suppliers

Tibolone3-EthyleneKetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tibolone 3-Ethylene Ketal

There total 3 articles about Tibolone 3-Ethylene Ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one (1162-60-3) + ethylene glycol (107-21-1) → 7α-methylnorethynodrel ethylene ketal (677299-58-0)

Guidance literature:

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one; ethylene glycol; With toluene-4-sulfonic acid; In water; toluene; at 65 ℃; for 0.0333333h;

With orthoformic acid triethyl ester; at 63 - 65 ℃; for 0.916667h;

With sodium hydrogencarbonate; for 0.0833333h;

Reference yield: 54.0%

3,3-ethylenedioxy-7α-methyl-5(10)-estren-17-one (141664-12-2) + acetylene (74-86-2,25067-58-7) → 7α-methylnorethynodrel ethylene ketal (677299-58-0)

Guidance literature:

acetylene; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

7α-methyl-3,3-(ethylenedioxy)-5(10)-estren-17-one; acetylene; In tetrahydrofuran; at 4 - 8 ℃; for 4h;

With ammonium chloride; In water; toluene; at 0 - 20 ℃; for 1.75h;

Reference yield:

7α-methyl-19-nortestosterone (3764-87-2) + ethylene glycol (107-21-1) + lithium acetylide (70277-75-7) → 7α-methylnorethynodrel ethylene ketal (677299-58-0) + C23H32O3

Guidance literature:

With sodium acetate; toluene-4-sulfonic acid; ethylenediamine; pyridinium chlorochromate; Multistep reaction. Title compound not separated from byproducts;

DOI:10.1016/0039-128X(93)90012-C

upstream raw materials:

7α-methyl-19-nortestosterone

ethylene glycol

lithium acetylide

3,3-ethylenedioxy-7α-methyl-5(10)-estren-17-one

Downstream raw materials:

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

tibolone

10β-hydroperoxy-7α-methylnorethindrone 17-heptanoate

Refernces

• 1、 Hoyte, Robert M.,Brown, Theodore J.,MacLusky, Neil J.,Hochberg, Richard B.. "7α-Methy-17α-(E-2′[ 125l]iodvinyl)-19-nortestosterone: A new radioligand for the detection of androgen receptor". . p. 13 - 23. Retrieved 2007/10/02.