Chemical Property of Tibolone
Chemical Property:
- Appearance/Colour:white solid
- Vapor Pressure:6.96E-10mmHg at 25°C
- Melting Point:169 °C
- Refractive Index:105 ° (C=0.54, CH2Cl2/Et2O)
- Boiling Point:447.4 °C at 760 mmHg
- PKA:13.10±0.60(Predicted)
- Flash Point:190.6 °C
- PSA：37.30000
- Density:1.13 g/cm3
- LogP:3.88260
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble15mg/mL, clear
- XLogP3:2.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:312.208930132
- Heavy Atom Count:23
- Complexity:636
- Purity/Quality:
-
99% *data from raw suppliers
Tibolone ≥98% (HPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
51/53
- Safety Statements:
22-24/25-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Synthetic Estrogen
- Canonical SMILES:CC1CC2=C(CCC(=O)C2)C3C1C4CCC(C4(CC3)C)(C#C)O
- Isomeric SMILES:C[C@@H]1CC2=C(CCC(=O)C2)[C@@H]3[C@@H]1[C@@H]4CC[C@]([C@]4(CC3)C)(C#C)O
- Recent ClinicalTrials:The Effects of Luo-Bu-Fu-Ke-Bi-RI Pill on Climacteric Syndrome in Women
- Recent EU Clinical Trials:A Multicenter, Randomized, Double-Blind, Placebo- And Active-Controlled Study of DVS-233 SR for Treatment of Vasomotor Symptoms Associated with Menopause
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Description
Tibolone is a synthetic steroid with weak progestational and estrogenic properties,
reportedly useful in controlling symptoms resulting from natural or surgical menopause.
It has thus far shown no significant antithrombotic effect in post-menopausal patients.
-
Uses
A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome
-
Clinical Use
Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to
alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of
menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable
alternative to conjugated equine estrogen plus micronized progesterone.
