N-(tert-Butyloxy)carbonyl-L-thyroxine

Base Information

• Chemical Name: N-(tert-Butyloxy)carbonyl-L-thyroxine
• CAS No.: 88404-22-2
• Molecular Formula: C₂₀H₁₉I₄NO₆
• Molecular Weight: 876.992
• Mol file: 88404-22-2.mol

Synonyms:N-(tert-Butyloxy)carbonyl-L-thyroxine

Chemical Property of N-(tert-Butyloxy)carbonyl-L-thyroxine

Chemical Property:

• Melting Point: 212 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 660.0±55.0 °C(Predicted)
• PKA: 2.78±0.10(Predicted)
• PSA: 105.09000
• Density: 2.272±0.06 g/cm3(Predicted)
• LogP: 6.51420
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

98%min ^*data from raw suppliers

N-(tert-Butyloxy)carbonyl-L-thyroxine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(tert-Butyloxy)carbonyl-L-thyroxine is used in the preparation of Thyroxine (T425601) analogue biosensors for use on the BIAcore surface plasmon resonance instrument.

Technology Process of N-(tert-Butyloxy)carbonyl-L-thyroxine

There total 15 articles about N-(tert-Butyloxy)carbonyl-L-thyroxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + L-thyroxine (51-48-9,24486-40-6) → (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid (88404-22-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2010.04.011

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + thyroxine (300-30-1,24486-40-6) → 2-[(tert-butoxycarbonyl)amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid (88404-22-2)

Guidance literature:

In N,N-dimethyl-formamide; for 2h;

Reference yield: 82.0%

dextrothyroxine sodium + di-tert-butyl dicarbonate (24424-99-5) → BOC-D-Thx-OH (89624-64-6,88404-22-2)

Guidance literature:

With hydrogenchloride; In N-methyl-acetamide; methanol;

upstream raw materials:

di-tert-butyl dicarbonate

L-thyroxine

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

L-tyrosine