methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

Base Information

Chemical Name:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate
CAS No.:1431868-09-5
Molecular Formula:C₂₁H₂₁I₄NO₆
Molecular Weight:891.019
Hs Code.:

Synonyms:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

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Chemical Property of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

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Technology Process of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

There total 6 articles about methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: methyl (S)-2-amino-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate hydrochloride

: 1431868-09-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 128781-80-6
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate

: 1431868-09-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

3: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C

With pyridine; tetrabutyl ammonium fluoride; copper diacetate; Iodine monochloride; N-butylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2011.639005

Reference yield:

: 1080-06-4
L-Tyr-OMe

: 1431868-09-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / water; tetrahydrofuran / 24 h / 20 °C

2: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

5: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C

With pyridine; N-iodo-succinimide; tetrabutyl ammonium fluoride; copper diacetate; Iodine monochloride; sodium hydrogencarbonate; N-butylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2011.639005