(S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate
CAS No.:1306763-30-3
Molecular Formula:C₁₅H₁₈N₂O₂
Molecular Weight:258.32
Hs Code.:
Mol file:1306763-30-3.mol

Synonyms:(S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate;Ozanimod intermediate 1

Suppliers and Price of (S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate
100mg
$ 220.00

Crysdot
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 97%
1g
$ 376.00

Ambeed
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 97%
250mg
$ 98.00

Ambeed
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 97%
100mg
$ 49.00

Ambeed
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 97%
1g
$ 178.00

Alichem
(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate
1g
$ 400.00

AK Scientific
(R)-Tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate
1g
$ 300.00

AK Scientific
(R)-Tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate
100mg
$ 126.00

Total 13 raw suppliers

Chemical Property of (S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property:

Boiling Point:411.9±44.0 °C(Predicted)
PKA:11.86±0.20(Predicted)
PSA：62.12000
Density:1.15±0.1 g/cm3(Predicted)
LogP:3.46118
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-tert-Butyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (R)-tert-Butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate is a useful reagent in the preparation of oxadiazoles as sphingosine 1 phosphate receptor modulators useful in the treatment of S1P1-associated diseases.

Technology Process of (S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

There total 5 articles about (S)-tert-butyl (4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1306763-29-0,1213591-14-0
(R)-(1-amino-2,3-dihydro-1H-indene-1-yl)-4-carbonitrile hydrochloride

: 1306763-30-3
(R)-tert-butyl 4-cyano-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1306763-30-3
(R)-tert-butyl 4-cyano-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 7 h / 95 °C / Inert atmosphere

2: titanium(IV) tetraethanolate / toluene / 12 h / 60 °C / Inert atmosphere

3: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrahydrofuran; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

: 60899-34-5
4-cyano-2,3-dihydro-1H-inden-1-one

: 1306763-30-3
(R)-tert-butyl 4-cyano-2,3-dihydro-1H-inden-1-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: titanium(IV) tetraethanolate / toluene / 12 h / 60 °C / Inert atmosphere

2: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrahydrofuran; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; triethylamine; In 1,4-dioxane; dichloromethane; toluene;