(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

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Chemical Name:(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate
CAS No.:1306763-42-7
Molecular Formula:C₂₃H₃₉N₃O₄Si
Molecular Weight:449.666
Hs Code.:

Synonyms:(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

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Chemical Property of (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

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Technology Process of (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

There total 9 articles about (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1306763-41-6
(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate

: 1306763-42-7,1306763-62-1
(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In ethanol; at 85 ℃; for 12h;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1306763-42-7,1306763-62-1
(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 7 h / 95 °C / Inert atmosphere

2.1: titanium(IV) tetraethanolate / toluene / 12 h / 60 °C / Inert atmosphere

3.1: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C / Cooling with ice

6.2: 1 h / 0 - 20 °C

7.1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 12 h / 85 °C

With tetrahydrofuran; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1306763-30-3
(R)-tert-butyl 4-cyano-2,3-dihydro-1H-inden-1-ylcarbamate

: 1306763-42-7,1306763-62-1
(R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C / Cooling with ice

1.2: 1 h / 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 12 h / 85 °C

With hydroxylamine hydrochloride; sodium hydride; sodium carbonate; In ethanol; N,N-dimethyl-formamide;