(E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide
• CAS No.: 219915-67-0
• Molecular Formula: C20H23N3O3S
• Molecular Weight: 385.487
• Mol file: 219915-67-0.mol

Synonyms:(E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide;1-(Phenylglyoxylyl)piperidine p-toluenesulfonylhydrazone;4-Methylbenzenesulfonic acid 2-[2-oxo-1-phenyl-2-(1-piperidinyl)ethylidene]hydrazide

Chemical Property of (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide

Chemical Property:

• Boiling Point: 543.4±43.0 °C(Predicted)
• PKA: 6.77±0.40(Predicted)
• PSA: 87.22000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 4.09970

Purity/Quality:

97% ^*data from raw suppliers

(E)-4-methyl-N''-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide

There total 5 articles about (E)-4-Methyl-N'-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(phenylglyoxylyl)piperidine (14377-63-0) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N’-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfono hydrazide (219915-67-0)

Guidance literature:

With sulfuric acid; In ethanol; for 2h; Reflux; Large scale;

Reference yield:

piperidine (110-89-4) → 4-methyl-N’-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfono hydrazide (219915-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / 50 - 55 °C / Large scale

2: sulfuric acid / ethanol / 2 h / Reflux; Large scale

With sulfuric acid; In methanol; ethanol;

Reference yield:

methyl 2-oxo-2-phenylacetate (15206-55-0) → 4-methyl-N’-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfono hydrazide (219915-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h / 50 - 55 °C / Large scale

2: sulfuric acid / ethanol / 2 h / Reflux; Large scale

With sulfuric acid; In methanol; ethanol;

upstream raw materials:

1-(phenylglyoxylyl)piperidine

toluene-4-sulfonic acid hydrazide

piperidine

phenylglyoxylic acid ethyl ester

Downstream raw materials:

7-phenyl-1-aza-bicyclo[4.2.0]octan-8-one

7-phenyl-1-azabicyclo<4.2.0>octan-8-one

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