Rosuvastatin Substituted Hydroxy Pentenoic Acid

Base Information

• Chemical Name: Rosuvastatin Substituted Hydroxy Pentenoic Acid
• CAS No.: 910867-11-7
• Molecular Formula: C20H24FN3O5S
• Molecular Weight: 437.492
• Mol file: 910867-11-7.mol

Synonyms:Rosuvastatin Substituted Hydroxy Pentenoic Acid

Chemical Property of Rosuvastatin Substituted Hydroxy Pentenoic Acid

Chemical Property:

• PSA: 129.07000
• LogP: 3.73150

Purity/Quality:

> 95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Rosuvastatin Substituted Hydroxy Pentenoic Acid

There total 1 articles about Rosuvastatin Substituted Hydroxy Pentenoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid R-(+)-α-methylbenzylamine salt (1024024-31-4) → (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid (910867-11-7)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 2 - 5 ℃; pH=3 - 3.5;

Reference yield: 95.0%

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid (910867-11-7) + tert-butyldimethylsilyl chloride (18162-48-6) → (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-(3S)-3-(O-tert-butyldimethylsilyl)-4-pentenoic acid (1045601-11-3)

Guidance literature:

tert-butyldimethylsilyl chloride; With potassium iodide; In N,N-dimethyl-formamide; at 25 - 60 ℃; for 0.5h;

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid; With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2.66667h;

Reference yield:

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid (910867-11-7) + potassium monomethyl malonate (69282-28-6) → methyl (6E)-7-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}(5S)-5-hydroxy-3-oxo-6-heptenoate (912337-61-2)

Guidance literature:

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 25 - 29 ℃; for 2.08333h;

potassium monomethyl malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; at 25 - 35 ℃; for 26h;

upstream raw materials:

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid R-(+)-α-methylbenzylamine salt

Downstream raw materials:

(3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-(3S)-3-(O-tert-butyldimethylsilyl)-4-pentenoic acid

methyl (6E)-7-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}(5S)-5-hydroxy-3-oxo-6-heptenoate