(3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester

Base Information

• Chemical Name: (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester
• CAS No.: 910867-12-8
• Molecular Formula: C₂₁H₂₆FN₃O₅S
• Molecular Weight: 451.519
• Mol file: 910867-12-8.mol

Synonyms:(3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester

Chemical Property of (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester

There total 4 articles about (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate (925421-76-7) → (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester (910867-12-8)

Guidance literature:

methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate; With ammonium fluoride; acetic acid; at 77 - 80 ℃; for 2.5h;

With potassium phosphate; In water; toluene;

Reference yield:

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid (910867-11-7) → (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester (910867-12-8)

Guidance literature:

methanol; With acetyl chloride; at -5 - 5 ℃; for 0.666667h;

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid; at 0 - 29 ℃; for 3.66667 - 4.66667h;

With sodium hydrogencarbonate; at 0 ℃;

Reference yield:

methanol (67-56-1) + (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-4-pentenoic acid (1S)-2-hydroxy-1,2,2-triphenylethyl ester (1024024-27-8) → (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester (910867-12-8)

Guidance literature:

With potassium carbonate; at 20 ℃; for 3h;

upstream raw materials:

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid

methyl (3S,E)-5-(4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-yl)-3-tert-butyldimethylsilyloxy-pent-4-enoate

methanol

(3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-4-pentenoic acid (1S)-2-hydroxy-1,2,2-triphenylethyl ester

Downstream raw materials:

(5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-5-(hydroxy)-3-oxo-(6E)-heptenoic acid tert-butyl ester