Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Base Information

Chemical Name:Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate
CAS No.:2473-19-0
Molecular Formula:C₁₃H₁₆O₃
Molecular Weight:220.268
Hs Code.:
DSSTox Substance ID:DTXSID60516677
Nikkaji Number:J2.454.919D

Synonyms:2473-19-0;Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate;2-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-6-methoxy-, methyl ester;SCHEMBL8076218;DTXSID60516677;RVRLWBZKHLMAEM-UHFFFAOYSA-N;Methyl 1,2,3,4-Tetrahydro-6-methoxynaphthalene-2-carboxylate;Methyl6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate;AKOS016005434;methyl 6-methoxy-1,2,3,4- tetrahydro-2-naphthoate;methyl 6-methoxy-1,2,3,4-tetrahydro-2-naphthoate

Suppliers and Price of Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 6 raw suppliers

Chemical Property of Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:220.109944368
Heavy Atom Count:16
Complexity:252

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(CC(CC2)C(=O)OC)C=C1

Technology Process of Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

There total 2 articles about Methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935740-89-9
[4-methoxy-2-{(trimethylsilyl)methyl}phenyl]methyl methyl carbonate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 2473-19-0
methyl 1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylate

: 65844-56-6
methyl 1,2,3,4-tetrahydro-7-methoxy-2-naphthalenecarboxylate

Guidance literature:: DPPE-Pd(η³-C3H5)Cp; In dimethyl sulfoxide; at 120 ℃; for 72h; Title compound not separated from byproducts.;
DOI:10.1021/ja070012l

Reference yield:

: 83781-48-0
<2-((trimethylsilyl)methyl)-5-methoxybenzyl>trimethylammonium iodide

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 2473-19-0
methyl 1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylate

: 65844-56-6
methyl 1,2,3,4-tetrahydro-7-methoxy-2-naphthalenecarboxylate

Guidance literature:: With tetra(tert-butyl)-ammonium fluoride; In acetonitrile; for 1h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/ja00390a036

Reference yield:

: 2473-19-0
methyl 1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylate

: 1289560-73-1
oxazol-2-yl(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux

2.1: sulfuric acid / 1 h / Inert atmosphere; Reflux

3.1: pyridine / 0 - 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

7.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

7.2: 0.67 h / -78 °C

7.3: 2 h / -78 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sulfuric acid; water; hydrogen bromide; sodium carbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; water; 4.1: Suzuki coupling;
DOI:10.1021/jm101597x