4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:885693-01-6
Molecular Formula:C22H32N2O2
Molecular Weight:356.508
Hs Code.:

Synonyms:4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

PSA：55.56000
LogP:5.85980

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(4-AMino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 885693-00-5
4-(4-amino-3-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 885693-01-6
4-(4-amino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 3h;

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 885693-01-6
4-(4-amino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / 1,4-dioxane; ethanol; water; toluene / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr

3: N-Bromosuccinimide / dichloromethane / 10 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 3 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; lithium chloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 1: Suzuki-Miyaura coupling / 4: Suzuki-Miyaura coupling;
DOI:10.1021/jm200900q

Reference yield:

: 873454-43-4
4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 885693-01-6
4-(4-amino-3-cyclohex-1-enyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 1034.32 Torr

2: N-Bromosuccinimide / dichloromethane / 10 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 3 h / 80 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In methanol; ethanol; dichloromethane; water; toluene; 3: Suzuki-Miyaura coupling;
DOI:10.1021/jm200900q