(R)-Eucomic acid

Base Information

• Chemical Name: (R)-Eucomic acid
• CAS No.: 60449-49-2
• Molecular Formula: C₁₃H₁₆O₆
• Molecular Weight: 268.266
• Mol file: 60449-49-2.mol

Synonyms:(3R)-3-Hydroxy-3-(4-hydroxybenzyl)butanedioic acid;(R)-2-Hydroxy-2-[(4-hydroxyphenyl)methyl]butanedioic acid;(R)-Eucomic acid;Eucomic acid

Chemical Property of (R)-Eucomic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-Eucomic acid

There total 2 articles about (R)-Eucomic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (2R)-2-(p-hydroxybenzyl)malic acid (60449-48-1) → eucomic acid dimethyl ester (60449-49-2)

Guidance literature:

With sulfuric acid; at 80 ℃; for 1h;

DOI:10.14233/ajchem.2014.16312

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (2R)-2-(p-hydroxybenzyl)malic acid (60449-48-1) → eucomic acid dimethyl ester (60449-49-2)

Guidance literature:

In diethyl ether;

DOI:10.1002/hlca.19740570628

Reference yield:

eucomic acid dimethyl ester (60449-49-2) → (R)-2-(4-Methoxy-benzyl)-butane-1,2,4-triol (60449-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; acetone;

DOI:10.1002/hlca.19740570628

upstream raw materials:

diazomethane

(2R)-2-(p-hydroxybenzyl)malic acid

methanol

Downstream raw materials:

(R)-2-(4-Methoxy-benzyl)-butane-1,2,4-triol