tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate
CAS No.:1426699-08-2
Molecular Formula:C₁₈H₂₅Cl₂NO₃
Molecular Weight:374.307
Hs Code.:

Synonyms:tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

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Technology Process of tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

There total 4 articles about tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382996-71-5
tert-butyl 3-(3-acetyl-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

: 1426699-08-2
tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 - 5 °C

2: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 1382995-35-8
1-(5-chloro-3-iodo-2-methoxy-4-methylphenyl)ethan-1-one

: 1426699-08-2
tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 70 °C

2.1: sodium tetrahydroborate; methanol / 1 h / 0 - 5 °C

3.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; ethylene dibromide; N,N-dimethyl-formamide; zinc; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1426699-08-2
tert-butyl 3-[3-chloro-5-(1-chloroethyl)-6-methoxy-2-methylphenyl]azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / acetic acid / 3.5 h / 60 - 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 - 5 °C

5.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

With methanol; sodium tetrahydroborate; N-iodo-succinimide; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; ethylene dibromide; N,N-dimethyl-formamide; zinc; In dichloromethane; acetic acid; N,N-dimethyl-formamide;