spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride

Base Information

• Chemical Name: spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride
• CAS No.: 231938-20-8
• Molecular Formula: C13H16ClNO
• Molecular Weight: 237.729
• Hs Code.: 2933399090
• Mol file: 231938-20-8.mol

Synonyms:spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride

Chemical Property of spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride

Chemical Property:

• PSA: 29.10000
• LogP: 3.02500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Spiro[indene-1,4''-piperidin]-3(2H)-onehydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride

There total 1 articles about spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester (159634-59-0) → spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride (231938-20-8)

Guidance literature:

With hydrogenchloride; methanol;

Reference yield: 99.0%

spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride (231938-20-8) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate (878167-49-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride (231938-20-8) + benzyl bromide (100-39-0) → 1'-benzyl-spiro[1H-indene-1,4'-piperidin]-3(2H)-one (873056-16-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

upstream raw materials:

2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

Downstream raw materials:

benzyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

1,2,3,4-tetrahydroquinolin-4-spiro-4'-(N'-benzylpiperidine)

1'-benzyl-spiro[1H-indene-1,4'-piperidin]-3(2H)-one

Refernces

• 1、 -. "SPIRO CONDENSED PIPERIDNES AS MODULATORS OF MUSCARINIC RECEPTORS". Page/Page column 53. . Retrieved 2008/06/13.
• 2、 -. "Spiropiperidine derivatives". . . Retrieved 2008/06/13.