1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone

Base Information

Chemical Name:1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone
CAS No.:914221-54-8
Molecular Formula:C9H8BrFO2
Molecular Weight:247.064
Hs Code.:
Mol file:914221-54-8.mol

Synonyms:4-Acetyl-2-bromo-5-fluoro-anisole

Suppliers and Price of 1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
1-(5-Bromo-2-fluoro-4-methoxy-phenyl)-ethanone ＞97%
1 G
$ 295.00

American Custom Chemicals Corporation
4-ACETYL-2-BROMO-5-FLUORO-ANISOLE 95.00%
1G
$ 1030.84

Alichem
1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone
5g
$ 922.18

Total 6 raw suppliers

Chemical Property of 1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone

Chemical Property:

Vapor Pressure:0.00121mmHg at 25°C
Boiling Point:299.2°C at 760 mmHg
Flash Point:134.8°C
PSA：26.30000
Density:1.494g/cm³
LogP:2.79940
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromo-2-fluoro-4-methoxy-phenyl)-ethanone ＞97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone

There total 7 articles about 1-(5-Bromo-2-fluoro-4-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

: 75-36-5
acetyl chloride

: 914221-54-8
1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one

Guidance literature:: With aluminum (III) chloride; In 1,2-dichloro-ethane; at -10 - 5 ℃; for 1h;

Reference yield: 78.0%

: 35310-75-9
3-bromo-4-methoxyacetophenone

: 914221-54-8
1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one

Guidance literature:: With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate; In dichloromethane; at 95 ℃; for 24h; Sealed tube;
DOI:10.1039/d1cc01047f

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 914221-54-8
1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 65 °C

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1.17 h / 0 - 10 °C / Inert atmosphere; Large scale reaction

2.2: 0 - 20 °C / Large scale reaction

With aluminum (III) chloride; In tetrahydrofuran; 1,2-dichloro-ethane; 2.1: Friedel-Crafts acylation;
DOI:10.1021/jo1018574