1-(4-Bromophenyl)cyclopropanol

Base Information

• Chemical Name: 1-(4-Bromophenyl)cyclopropanol
• CAS No.: 109240-30-4
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.074
• European Community (EC) Number: 836-878-4
• Mol file: 109240-30-4.mol

Synonyms:1-(4-bromophenyl)cyclopropanol;109240-30-4;1-(4-bromophenyl)cyclopropan-1-ol;Cyclopropanol, 1-(4-bromophenyl)-;SCHEMBL15573716;CKWRAYGCDLYUSQ-UHFFFAOYSA-N;MFCD16840915;AKOS005266641;AS-60102;CS-0157922;EN300-142196;W18259;F8889-4304

Chemical Property of 1-(4-Bromophenyl)cyclopropanol

Chemical Property:

• Melting Point: 78-79 °C
• Boiling Point: 289.7±23.0 °C(Predicted)
• PKA: 14.29±0.20(Predicted)
• PSA: 20.23000
• Density: 1.651±0.06 g/cm3(Predicted)
• LogP: 2.43050
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 211.98368
• Heavy Atom Count: 11
• Complexity: 146

Purity/Quality:

99.3% ^*data from raw suppliers

1-(4-Bromophenyl)cyclopropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(C2=CC=C(C=C2)Br)O

Technology Process of 1-(4-Bromophenyl)cyclopropanol

There total 11 articles about 1-(4-Bromophenyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

diiodomethane (75-11-6) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 1-(4-bromophenyl)cyclopropan-1-ol (109240-30-4)

Guidance literature:

With samarium; In tetrahydrofuran; at 0 ℃; for 0.333333h;

DOI:10.1016/S0040-4039(00)84764-4

Reference yield: 63.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-(4-bromophenyl)-1-(trimethylsilyloxy)ethylene (55991-66-7) → 1-(4-bromophenyl)cyclopropan-1-ol (109240-30-4)

Guidance literature:

With iodine; triethylaluminum; In dichloromethane; at 0 - 23 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1007/s11172-019-2638-5

Reference yield: 63.0%

diiodomethane (75-11-6) + 1-(4-bromophenyl)-1-(trimethylsilyloxy)ethylene (55991-66-7) → 1-(4-bromophenyl)cyclopropan-1-ol (109240-30-4)

Guidance literature:

diiodomethane; 1-(4-bromophenyl)-1-(trimethylsilyloxy)ethylene; With diethylzinc; In diethyl ether; hexane; at 0 ℃; for 4h; Reflux;

With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/ja905110c

upstream raw materials:

diiodomethane

para-bromophenacyl bromide

dichloromethane

para-bromoacetophenone

Downstream raw materials:

[1-(4-bromophenyl)cyclopropoxy](tert-butyl)dimethylsilane

3-bromo-1-(4-bromophenyl)propan-1-one