(R)-3-chloro-1-(4-fluorophenyl)propan-1-ol

Base Information

• Chemical Name: (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol
• CAS No.: 200004-39-3
• Molecular Formula: C9H10ClFO
• Molecular Weight: 188.629
• Mol file: 200004-39-3.mol

Synonyms:(R)-3-chloro-1-(4-fluorophenyl)propan-1-ol;(alphaR)-alpha-(2-Chloroethyl)-4-fluorobenzenemethanol

Chemical Property of (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 2.48800

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol

There total 6 articles about (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-chloro-4'-fluoropropiophenone (347-93-3) → (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol (200004-39-3)

Guidance literature:

With sodium tetrahydroborate; chloro-trimethyl-silane; (S)-diphenylprolinol; In tetrahydrofuran; at 25 - 70 ℃; for 1h;

DOI:10.1016/S0040-4039(00)01848-7

Reference yield: 26.0%

vinyl n-butyrate (123-20-6,24991-31-9) + 3-chloro-1-(4-fluorophenyl)propan-1-ol (31736-75-1) → (R)-3-chloro-1-(4-fluorophenyl)propyl butyrate (1345507-84-7) + (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol (200004-39-3) + (S)-3-chloro-1-(4-fluorophenyl)propan-1-ol (200004-40-6)

Guidance literature:

With lipase from Pseudomonas fluorescens; In hexane; at 20 ℃; for 19h; optical yield given as %ee; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1055/s-0030-1260149

Reference yield: 24.0%

(R)-3-chloro-1-(4-fluorophenyl)propyl butyrate (1345507-84-7) → (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol (200004-39-3)

Guidance literature:

With lipase from Candida rugosa; at 20 ℃; for 1.5h; pH=8; stereoselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1055/s-0030-1260149

upstream raw materials:

3-chloro-4'-fluoropropiophenone

(R)-3-chloro-1-(4-fluorophenyl)propyl butyrate

vinyl n-butyrate

3-chloro-1-(4-fluorophenyl)propan-1-ol

Downstream raw materials:

(R)-1-(4-Fluoro-phenyl)-3-iodo-propan-1-ol